Gene
slc12a3
- ID
- ZDB-GENE-030131-9505
- Name
- solute carrier family 12 member 3
- Symbol
- slc12a3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable sodium:potassium:chloride symporter activity. Acts upstream of or within cloaca development and pronephric duct morphogenesis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including blood; intermediate mesoderm; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 90 figures from 42 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7153737 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abu Seman et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-slc12a3 | (2) | |
MO1-slc12a3 | N/A | Abu Seman et al., 2014 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Gitelman syndrome | Alliance | Gitelman syndrome | 263800 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Amino acid permease, N-terminal | Amino acid permease/ SLC12A domain | SLC12A transporter, C-terminal | SLC12A transporter family | Thiazide-sensitive Na-K-Cl co-transporter |
---|---|---|---|---|---|---|---|
UniProtKB:Q1LX46 | InterPro | 1012 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
slc12a3-201
(1)
|
Ensembl | 3,792 nt | ||
mRNA |
slc12a3-203
(1)
|
Ensembl | 4,208 nt | ||
ncRNA |
slc12a3-002
(1)
|
Ensembl | 560 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab3-slc12a3 | polyclonal | Rabbit |
|
1 | |||
Ab2-slc12a3 | polyclonal | Rabbit |
|
1 | |||
Ab1-slc12a3 | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-122C9 | ZFIN Curated Data | |
Encodes | EST | fj83c03 | ||
Encodes | EST | IMAGE:7153737 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:174979 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001045080 (1) | 3792 nt | ||
Genomic | GenBank:BX470170 (2) | 108112 nt | ||
Polypeptide | UniProtKB:Q1LX46 (1) | 1012 aa |
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Abu Obaid, A., Ivandic, I., Korsching, S.I. (2024) Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis. Cellular and molecular life sciences : CMLS. 81:213213
- Ercanbrack, W.S., Dungan, A., Gaul, E., Ramirez, M., J DelVecchio, A., Grass, C., Wingert, R.A. (2024) Frataxin is essential for zebrafish embryogenesis and pronephros formation. Frontiers in cell and developmental biology. 12:14962441496244
- Ka, H.I., Cho, M., Kwon, S.H., Mun, S.H., Han, S., Kim, M.J., Yang, Y. (2023) IK is essentially involved in ciliogenesis as an upstream regulator of oral-facial-digital syndrome ciliopathy gene, ofd1. Cell & Bioscience. 13:195195
- Wesselman, H.M., Flores-Mireles, A.L., Bauer, A., Pei, L., Wingert, R.A. (2023) Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis. Development (Cambridge, England). 150(10):
- Wesselman, H.M., Gatz, A.E., Pfaff, M.R., Arceri, L., Wingert, R.A. (2023) Estrogen Signaling Influences Nephron Segmentation of the Zebrafish Embryonic Kidney. Cells. 12(4):
- Park, J.S., Gabel, A.M., Kassir, P., Kang, L., Chowdhary, P.K., Osei-Ntansah, A., Tran, N.D., Viswanathan, S., Canales, B., Ding, P., Lee, Y.S., Brewster, R. (2022) N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia. eLIFE. 11:
- Weaver, N.E., Healy, A., Wingert, R.A. (2022) gldc Is Essential for Renal Progenitor Patterning during Kidney Development. Biomedicines. 10(12):
- Fédou, C., Camus, M., Lescat, O., Feuillet, G., Mueller, I., Ross, B., Buléon, M., Neau, E., Alves, M., Goudounéche, D., Breuil, B., Boizard, F., Bardou, Q., Casemayou, A., Tack, I., Dreux, S., Batut, J., Blader, P., Burlet-Schiltz, O., Decramer, S., Wirth, B., Klein, J., Saulnier-Blache, J.S., Buffin-Meyer, B., Schanstra, J.P. (2021) Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies Plastin 3 as a protein involved in glomerular integrity. The Journal of pathology. 254(5):575-588
- Perens, E.A., Diaz, J.T., Quesnel, A., Askary, A., Crump, J.G., Yelon, D. (2021) osr1 couples intermediate mesoderm cell fate with temporal dynamics of vessel progenitor cell differentiation. Development (Cambridge, England). 148(15):
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