Gene
mmp2
- ID
- ZDB-GENE-030131-9123
- Name
- matrix metallopeptidase 2
- Symbol
- mmp2 Nomenclature History
- Previous Names
-
- Gelatinase A (1)
- wu:fa99h12
- wu:fk89d01
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Involved in positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hematopoietic stem cell migration; lymph vessel development; and neurogenesis. Located in sarcomere. Is expressed in several structures, including cardiovascular system; digestive system; integument; nervous system; and ovarian follicle. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 59 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136035 (1 image)
- IMAGE:7163203 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu10535 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| sa1218 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21006 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34122 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45285 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mmp2 | (2) | |
| CRISPR2-mmp2 | (2) | |
| CRISPR3-mmp2 | (2) | |
| CRISPR4-mmp2 | (2) | |
| CRISPR5-mmp2 | Charlton-Perkins et al., 2019 | |
| CRISPR6-mmp2 | Charlton-Perkins et al., 2019 | |
| CRISPR7-mmp2 | Weaver et al., 2020 | |
| MO1-mmp2 | N/A | (2) |
| MO2-mmp2 | N/A | Janssens et al., 2013 |
| MO3-mmp2 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Multicentric osteolysis, nodulosis, and arthropathy | 259600 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Kringle-like fold | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7SZM5 | InterPro | 657 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:SS-HA-ATTB-1-mmp2_E404A-ATTB2-EGFP) |
| 1 | Jeffrey et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-182H7 | ZFIN Curated Data | |
| Encodes | EST | fa99h12 | Dildrop et al., 2004 | |
| Encodes | EST | fk89d01 | ||
| Encodes | EST | IMAGE:7136035 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7163203 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92438 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198067 (1) | 2966 nt | ||
| Genomic | GenBank:BX663609 (2) | 248960 nt | ||
| Polypeptide | UniProtKB:Q7SZM5 (1) | 657 aa |
- Fietta, A., Fusco, P., Germano, G., Micheli, S., Sorgato, M., Lucchetta, G., Cimetta, E. (2024) Neuroblastoma-derived hypoxic extracellular vesicles promote metastatic dissemination in a zebrafish model. PLoS One. 19:e0316103e0316103
- Lai, Z.Y., Yang, C.C., Chen, P.H., Chen, W.C., Lai, T.Y., Lu, G.Y., Yang, C.Y., Wang, K.Y., Liu, W.C., Chen, Y.C., Liu, L.Y., Chuang, Y.J. (2024) Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration. Molecular biology reports. 51:604604
- Raterman, S.T., Wagener, F.A.D.T.G., Zethof, J., Cuijpers, V., Klaren, P.H.M., Metz, J.R., Von den Hoff, J.W. (2024) foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations. Developmental Dynamics : an official publication of the American Association of Anatomists. :
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- Morsli, S., Henriques, C.M., Ellis, P.S., Mortiboys, H., Baxendale, S., Loynes, C.A., Renshaw, S.A., Bellantuono, I. (2023) A p21-GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell. 22(6):e13835
- Seda, M., Crespo, B., Corcelli, M., Osborn, D.P., Jenkins, D. (2023) A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis. Scientific Reports. 13:67836783
- Džulová, D., Lawless, D., Pinton, G.G., Renner, N.A., Schorderet, D.F. (2022) Incomplete Recovery of Zebrafish Retina Following Cryoinjury. Cells. 11(8):
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Rana, A.K., Sharma, S., Saini, S.K., Singh, D. (2022) Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model. European Journal of Pharmacology. 925:174973
- Rolland, L., Harrington, A., Faucherre, A., Abaroa, J.M., Gangatharan, G., Gamba, L., Severac, D., Pratlong, M., Moore-Morris, T., Jopling, C. (2022) The regenerative response of cardiac interstitial cells. Journal of molecular cell biology. 14(10):
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