Gene
sparc
- ID
- ZDB-GENE-030131-9
- Name
- secreted protein, acidic, cysteine-rich (osteonectin)
- Symbol
- sparc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; inner ear morphogenesis; and pharyngeal system development. Predicted to be located in basement membrane and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranium; hematopoietic system; pectoral fin; pectoral fin bud; and vestibuloauditory system. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6910025 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018906Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027518Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa22480 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22481 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| ue112 | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sparc | Keatinge et al., 2021 | |
| CRISPR2-sparc | (2) | |
| CRISPR3-sparc | Debaenst et al., 2025 | |
| CRISPR4-sparc | Ye et al., 2025 | |
| CRISPR5-sparc | Lin et al., 2025 | |
| MO1-sparc | N/A | (2) |
| MO2-sparc | N/A | (2) |
| MO3-sparc | N/A | (2) |
| MO4-sparc | N/A | Kang et al., 2008 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteogenesis imperfecta type 17 | Alliance | Osteogenesis imperfecta, type XVII | 616507 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EF-Hand 1, calcium-binding site | EF-hand domain pair | Follistatin-like, N-terminal | Follistatin/Osteonectin EGF domain | Kazal domain | Kazal domain superfamily | Osteonectin-like, conserved site | SPARC, follistatin-like domain | SPARC/Testican, calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IQH0 | InterPro | 291 | |||||||||
| UniProtKB:A0AB32T306 | InterPro | 282 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-97O1 | ZFIN Curated Data | |
| Contains | SNP | rs3727771 | ||
| Contains | SNP | rs3727772 | ||
| Contains | SNP | rs3727773 | ||
| Contains | SNP | rs3727774 | ||
| Encodes | EST | IMAGE:6910025 | Thisse et al., 2004 | |
| Encodes | EST | zeh0062 | ||
| Encodes | cDNA | MGC:86767 | ZFIN Curated Data | |
| Has Artifact | EST | fa96a08 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001001942 (1) | 1688 nt | ||
| Genomic | GenBank:BX640507 (2) | 189019 nt | ||
| Polypeptide | UniProtKB:Q6IQH0 (1) | 291 aa |
- Debaenst, S., Jarayseh, T., De Saffel, H., Bek, J.W., Boone, M., Josipovic, I., Kibleur, P., Kwon, R.Y., Coucke, P.J., Willaert, A. (2025) Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility. eLIFE. 13:
- Gjorcheska, S., Paudel, S., McLeod, S., Paulding, D., Snape, L., Sosa, K.C., Duan, C., Kelsh, R., Barske, L. (2025) Sox10 is required for systemic initiation of bone mineralization. Development (Cambridge, England). 152(2):
- Ye, W., Shi, M., Cheng, Y., Liu, Y., Ren, K., Fang, Y., Younas, W., Zhang, W., Wang, Y., Xia, X.Q. (2025) Integrated single-cell transcriptome and comparative genome analysis reveal origin of intermuscular bones in zebrafish. International journal of biological macromolecules. :142397142397
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Guo, W., Jin, P., Li, R., Huang, L., Liu, Z., Li, H., Zhou, T., Fang, B., Xia, L. (2023) Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis. Experimental & molecular medicine. 55(1):81-94
- Jin, Z., Wang, D., Lv, H., Wu, B., Li, Z., Guo, X., Wang, H., Yang, S. (2023) Loss of the adaptor protein Sh3bgrl initiates ovarian fibrosis in zebrafish. FEBS letters. 597(21):2643-2655
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
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