Gene
slc1a2b
- ID
- ZDB-GENE-030131-7779
- Name
- solute carrier family 1 member 2b
- Symbol
- slc1a2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable L-glutamate transmembrane transporter activity; glutamate:sodium symporter activity; and neutral L-amino acid transmembrane transporter activity. Acts upstream of or within larval locomotory behavior and regulation of glutamate uptake involved in transmission of nerve impulse. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and spinal cord neural tube. Used to study developmental and epileptic encephalopathy 41. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023360Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15717 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tk57 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zh7 | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc1a2b | (3) | |
| MO1-slc1a2b | N/A | McKeown et al., 2012 |
| MO2-slc1a2b | N/A | Niklaus et al., 2017 |
| MO3-slc1a2b | N/A | Niklaus et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 41 | Alliance | Developmental and epileptic encephalopathy 41 | 617105 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| developmental and epileptic encephalopathy 41 | slc1a2bzh7/zh7 | standard conditions | Hotz et al., 2021 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dicarboxylate/Amino Acid:Cation Symporter | Sodium:dicarboxylate symporter | Sodium:dicarboxylate symporter, conserved site | Sodium:dicarboxylate symporter superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:D7RVR7 | InterPro | 523 | ||||
| UniProtKB:A0A8N7UZX7 | InterPro | 562 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc1a2b-201
(1)
|
Ensembl | 4,291 nt | ||
| mRNA |
slc1a2b-202
(1)
|
Ensembl | 4,033 nt | ||
| mRNA |
slc1a2b-204
(1)
|
Ensembl | 4,217 nt | ||
| mRNA |
slc1a2b-205
(1)
|
Ensembl | 1,637 nt | ||
| ncRNA |
ottdart00000056846
(1)
|
Ensembl | 258 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc1a2b | polyclonal | Chicken |
|
3 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(slc1a2b:Citrine) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-234I14 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-474I16 | ZFIN Curated Data | |
| Encodes | EST | fj34b12 | ||
| Encodes | cDNA | MGC:65897 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199979 (1) | 4291 nt | ||
| Genomic | GenBank:CU207301 (1) | 174391 nt | ||
| Polypeptide | UniProtKB:A0A8N7UZX7 (1) | 562 aa |
- O'Brown, N.M., Patel, N.B., Hartmann, U., Klein, A.M., Gu, C., Megason, S.G. (2023) The secreted neuronal signal spock1 promotes blood-brain barrier development. Developmental Cell. 58(17):1534-1547.e6
- Silva, N., Campinho, M.A. (2023) In a zebrafish biomedical model of human Allan-Herndon-Dudley syndrome impaired MTH signaling leads to decreased neural cell diversity. Frontiers in endocrinology. 14:11576851157685
- Ikeda, A., Yamasaki, C., Kubo, Y., Doi, Y., Komamizu, M., Komatsu, M., Shiozaki, K. (2022) Alteration of the neuronal and glial cell profiles in Neu1-deficient zebrafish. Glycoconjugate journal. 39(4):499-512
- Myren-Svelstad, S., Jamali, A., Ophus, S.S., D'gama, P.P., Ostenrath, A.M., Mutlu, A.K., Hoffshagen, H.H., Hotz, A.L., Neuhauss, S.C.F., Jurisch-Yaksi, N., Yaksi, E. (2022) Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. Epilepsia. 63:2543-2560
- Özsoy, Ç., Hotz, A.L., Rieser, N.N., Chen, Z., Deán-Ben, X.L., Neuhauss, S.C.F., Razansky, D. (2022) Volumetric optoacoustic neurobehavioral tracking of epileptic seizures in freely-swimming zebrafish larvae. Frontiers in molecular neuroscience. 15:1004518
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Hentig, J., Campbell, L.J., Cloghessy, K., Lee, M., Boggess, W., Hyde, D.R. (2021) Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2a. Biomedicines. 10(1):
- Hotz, A.L., Jamali, A., Rieser, N.N., Niklaus, S., Aydin, E., Myren-Svelstad, S., Lalla, L., Jurisch-Yaksi, N., Yaksi, E., Neuhauss, S.C.F. (2021) Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity. Glia. 70(1):196-214
- Umans, R.A., Pollock, C., Mills, W.A., Clark, K.C., Pan, Y.A., Sontheimer, H. (2021) Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development. Frontiers in cell and developmental biology. 9:654338
- Wang, X., Liao, Q., Chen, H., Gong, G., Siu, S.W.I., Chen, Q., Kam, H., Ung, C.O.L., Cheung, K.K., Rádis-Baptista, G., Wong, C.T.T., Lee, S.M. (2021) Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Frontiers in pharmacology. 12:763089
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