Gene

ptpn6

ID
ZDB-GENE-030131-7513
Name
protein tyrosine phosphatase non-receptor type 6
Symbol
ptpn6 Nomenclature History
Previous Names
  • fj22f05
  • SHP1 (1)
  • wu:fj22f05 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and phosphotyrosine residue binding activity. Acts upstream of or within several processes, including regulation of hematopoietic stem cell proliferation; regulation of leukocyte migration; and regulation of myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in blood island; gill; immune system; and liver. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hu12408Allele with one deletionUnknownUnknownCRISPR
sa6438Allele with one point mutationUnknownSplice SiteENU
sa22882Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With ptpn6 Human Ortholog
No data available
Associated With ptpn6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR000980 SH2 domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
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Domain Details Per Protein
Protein Additional Resources Length Non-receptor Tyrosine Phosphatase Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Protein-tyrosine phosphatase, non-receptor type-6, -11 SH2 domain SH2 domain superfamily Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:Q803M6 InterPro 589
UniProtKB:A0A2R8Q2T0 InterPro 590
UniProtKB:E7F3D4 InterPro 589
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 16
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ptpn6-201 (1) Ensembl 2,239 nt
mRNA ptpn6-202 (1) Ensembl 825 nt
mRNA ptpn6-203 (1) Ensembl 2,439 nt
mRNA ptpn6-204 (1) Ensembl 2,833 nt
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Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptpn6 polyclonal Rabbit
  • WB
2
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-57K11ZFIN Curated Data
EncodesESTfj22f05
EncodescDNAMGC:55501ZFIN Curated Data
EncodescDNAMGC:192937ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPTPN612
Conserved genome location (synteny) (1)
Amino acid sequence comparison (4)
MousePtpn66
Conserved genome location (synteny) (1)
Amino acid sequence comparison (3)
Citations
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