Gene
ptpn6
- ID
- ZDB-GENE-030131-7513
- Name
- protein tyrosine phosphatase non-receptor type 6
- Symbol
- ptpn6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable non-membrane spanning protein tyrosine phosphatase activity and phosphotyrosine residue binding activity. Acts upstream of or within several processes, including regulation of hematopoietic stem cell proliferation; regulation of leukocyte migration; and regulation of myeloid leukocyte differentiation. Predicted to be active in cytoplasm. Is expressed in blood island; gill; immune system; and liver. Orthologous to human PTPN6 (protein tyrosine phosphatase non-receptor type 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55501 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ptpn6 | Allers et al., 2023 | |
MO1-ptpn6 | N/A | (3) |
MO2-ptpn6 | N/A | Kanwal et al., 2013 |
MO3-ptpn6 | N/A | Kanwal et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR000980 | SH2 domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
Protein | Additional Resources | Length | Non-receptor Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase, non-receptor type-6, -11 | SH2 domain | SH2 domain superfamily | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q803M6 | InterPro | 589 | |||||||||
UniProtKB:A0A2R8Q2T0 | InterPro | 590 | |||||||||
UniProtKB:E7F3D4 | InterPro | 589 |
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Interactions and Pathways
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-57K11 | ZFIN Curated Data | |
Encodes | EST | fj22f05 | ||
Encodes | cDNA | MGC:55501 | ZFIN Curated Data | |
Encodes | cDNA | MGC:192937 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199960 (1) | 2125 nt | ||
Genomic | GenBank:BX511250 (1) | 189081 nt | ||
Polypeptide | UniProtKB:A0A2R8Q2T0 (1) | 590 aa |
- Allers, M., Bakker, P.A., Hoeksma, J., Spaink, H.P., den Hertog, J. (2023) Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae. Disease models & mechanisms. 16(2):
- van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
- Kossack, M.E., High, S.K., Hopton, R.E., Yan, Y.L., Postlethwait, J.H., Draper, B.W. (2018) Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Genetics. 211(1):219-233
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Benard, E.L., Racz, P.I., Rougeot, J., Nezhinsky, A.E., Verbeek, F.J., Spaink, H.P., Meijer, A.H. (2015) Macrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish. Journal of Innate Immunity. 7(2):136-52
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Minchin, J.E., Dahlman, I., Harvey, C.J., Mejhert, N., Singh, M.K., Epstein, J.A., Arner, P., Torres-Vazquez, J., Rawls, J.F. (2015) Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 112(14):4363-8
- Marín-Juez, R., Jong-Raadsen, S., Yang, S., Spaink, H.P. (2014) Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. The Journal of endocrinology. 222(2):229-41
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