Gene
socs3a
- ID
- ZDB-GENE-030131-7349
- Name
- suppressor of cytokine signaling 3a
- Symbol
- socs3a Nomenclature History
- Previous Names
-
- socs3
- fj09e12
- wu:fj09e12
- zgc:56537 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor binding activity. Acts upstream of or within several processes, including liver development; negative regulation of axon regeneration; and sensory system development. Is expressed in eye; female organism; lateral line; liver; and male organism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56537 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-socs3a | Avagyan et al., 2021 | |
| MO1-socs3a | N/A | (2) |
| MO2-socs3a | N/A | (2) |
| MO3-socs3a | N/A | Liang et al., 2012 |
| MO4-socs3a | N/A | Liang et al., 2012 |
| MO5-socs3a | N/A | Yin et al., 2012 |
| MO6-socs3a | N/A | Elsaeidi et al., 2014 |
| TALEN1-socs3a | (5) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SH2 domain | SH2 domain superfamily | SOCS3, SH2 domain | SOCS box domain | SOCS box-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZUC6 | InterPro | 207 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
socs3a-201
(1)
|
Ensembl | 1,935 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-socs3a | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255A4 | ||
| Encodes | EST | fj09e12 | ||
| Encodes | cDNA | MGC:56537 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199950 (1) | 1951 nt | ||
| Genomic | GenBank:AL953847 (2) | 144933 nt | ||
| Polypeptide | UniProtKB:Q7ZUC6 (1) | 207 aa |
- Tesoriere, A., Ghirardo, R., Terrin, F., Sernesi, F., Meneghetti, G., Dalla Valle, L., Dinarello, A., Argenton, F. (2025) Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway. International journal of biological sciences. 21:271284271-284
- Chen, X., Shen, Y., Song, Z., Wang, X., Yao, H., Cai, Y., Zhao, Z., Hu, B. (2024) microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation. Journal of genetics and genomics = Yi chuan xue bao. 51(9):911-921
- Lin, Y., Li, H., Zheng, S., Han, R., Wu, K., Tang, S., Zhong, X., Chen, J. (2024) Elucidating tobacco smoke-induced craniofacial deformities: Biomarker and MAPK signaling dysregulation unraveled by cross-species multi-omics analysis. Ecotoxicology and environmental safety. 288:117343117343
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Ulhaq, Z.S., Tse, W.K.F. (2024) PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease. Genes. 15(1):
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Madushani, K.P., Shanaka, K.A.S.N., Jung, S., Kim, M.J., Lee, J. (2023) Ablation of myd88 alters the immune gene expression and immune cell recruitment during VHSV infection in zebrafish. Fish & shellfish immunology. 141:109006
- Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):
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