Gene
prmt1
- ID
- ZDB-GENE-030131-693
- Name
- protein arginine methyltransferase 1
- Symbol
- prmt1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables histone H4R3 methyltransferase activity. Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adaxial cell; brain; heart; otic vesicle; and pleuroperitoneal region. Orthologous to human PRMT1 (protein arginine methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Tsai et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015171Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-prmt1 | N/A | (2) |
| MO2-prmt1 | N/A | Tsai et al., 2011 |
| MO3-prmt1 | N/A | Huang et al., 2013 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Methyltransferase domain 25 | Protein arginine N-methyltransferase | Protein arginine N-methyltransferase domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:F1R3J9 | InterPro | 348 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(prmt1:mCherry-Cre-ERT2) |
|
| 1 | Tavakoli et al., 2022 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-195B15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-16P21 | ZFIN Curated Data | |
| Encodes | EST | fb39h07 | ||
| Encodes | cDNA | MGC:66201 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200650 (1) | 2313 nt | ||
| Genomic | GenBank:BX511021 (2) | 235632 nt | ||
| Polypeptide | UniProtKB:F1R3J9 (1) | 348 aa |
- Muscò, A., Martini, D., Digregorio, M., Broccoli, V., Andreazzoli, M. (2024) Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Genes. 15(4):
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Tavakoli, S., Zhu, S., Matsudaira, P. (2022) Cell clusters containing intestinal stem cells line, the zebrafish intestine intervillus pocket. iScience. 25:104280
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Tsai, T.C., Shih, C.C., Chien, H.P., Yang, A.H., Lu, J.K., Lu, J.H. (2018) Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos. BMC Developmental Biology. 18:5
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Lin, Y.L., Tsai, Y.J., Liu, Y.F., Cheng, Y.C., Hung, C.M., Lee, Y.J., Pan, H., and Li, C. (2013) The Critical Role of Protein Arginine Methyltransferase prmt8 in Zebrafish Embryonic and Neural Development Is Non-Redundant with Its Paralogue prmt1. PLoS One. 8(3):e55221
1 - 10 of 17
Show