Gene

bmp15

ID
ZDB-GENE-030131-6115
Name
bone morphogenetic protein 15
Symbol
bmp15 Nomenclature History
Previous Names
  • fi35a05
  • wu:fi35a05
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable cytokine activity. Acts upstream of or within female sex differentiation; negative regulation of oocyte development; and oocyte maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and primary ovarian insufficiency. Orthologous to human BMP15 (bone morphogenetic protein 15).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
uc31Allele with one deletionUnknownPremature StopTALEN
umo35Allele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-bmp15 (2)
MO1-bmp15N/A (3)
TALEN1-bmp15 (3)
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Human Disease
Associated With bmp15 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 2 Alliance Ovarian dysgenesis 2 300510
ovarian dysgenesis 2 Alliance Premature ovarian failure 4 300510
primary ovarian insufficiency 4 Alliance Ovarian dysgenesis 2 300510
primary ovarian insufficiency 4 Alliance Premature ovarian failure 4 300510
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Associated With bmp15 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
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Domain Details Per Protein
Protein Additional Resources Length Cystine-knot cytokine Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q58FS4 InterPro 384
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 7
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA bmp15-201 (1) Ensembl 2,001 nt
mRNA bmp15-202 (1) Ensembl 640 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-bmp15 polyclonal Rabbit
  • IHC
  • WB
2
1 - 1 of 1
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-71A10ZFIN Curated Data
Contained inBACCH211-122F10ZFIN Curated Data
EncodesESTfi35a05
EncodescDNAMGC:152740ZFIN Curated Data
EncodescDNAMGC:191878ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanBMP15X
Amino acid sequence comparison (4)
MouseBmp15X
Amino acid sequence comparison (3)
Citations
1 - 10 of 39
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