Gene
bmp15
- ID
- ZDB-GENE-030131-6115
- Name
- bone morphogenetic protein 15
- Symbol
- bmp15 Nomenclature History
- Previous Names
-
- fi35a05
- wu:fi35a05
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within female sex differentiation; negative regulation of oocyte development; and oocyte maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and steroid hormone secreting cell. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and primary ovarian insufficiency. Orthologous to human BMP15 (bone morphogenetic protein 15).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-bmp15 | (2) | |
MO1-bmp15 | N/A | (3) |
TALEN1-bmp15 | (3) |
1 - 3 of 3
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
ovarian dysgenesis 2 | Alliance | Ovarian dysgenesis 2 | 300510 |
ovarian dysgenesis 2 | Alliance | Premature ovarian failure 4 | 300510 |
primary ovarian insufficiency 4 | Alliance | Ovarian dysgenesis 2 | 300510 |
primary ovarian insufficiency 4 | Alliance | Premature ovarian failure 4 | 300510 |
1 - 4 of 4
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cystine-knot cytokine | Transforming growth factor beta, conserved site | Transforming growth factor-beta, C-terminal | Transforming growth factor-beta-related |
---|---|---|---|---|---|---|
UniProtKB:Q58FS4 | InterPro | 384 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-71A10 | ZFIN Curated Data | |
Contained in | BAC | CH211-122F10 | ZFIN Curated Data | |
Encodes | EST | fi35a05 | ||
Encodes | cDNA | MGC:152740 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191878 | ZFIN Curated Data |
1 - 5 of 5
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020484 (1) | 1611 nt | ||
Genomic | GenBank:BX957362 (1) | 191638 nt | ||
Polypeptide | UniProtKB:Q58FS4 (1) | 384 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Bravo, P., Liu, Y., Draper, B.W., Marlow, F.L. (2023) Macrophage activation drives ovarian failure and masculinization in zebrafish. Science advances. 9:eadg7488
- Colella, M., Cuomo, D., Nittoli, V., Amoresano, A., Porciello, A., Reale, C., Roberto, L., Russo, F., Russo, N.A., De Felice, M., Mallardo, M., Ambrosino, C. (2023) A Cross-Species Analysis Reveals Dysthyroidism of the Ovaries as a Common Trait of Premature Ovarian Aging. International Journal of Molecular Sciences. 24(3):
- Wu, K., Zhai, Y., Qin, M., Zhao, C., Ai, N., He, J., Ge, W. (2023) Genetic evidence for differential functions of figla and nobox in zebrafish ovarian differentiation and folliculogenesis. Communications biology. 6:11851185
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Wang, Y., Ye, D., Zhang, F., Zhang, R., Zhu, J., Wang, H., He, M., Sun, Y. (2021) Cyp11a2 is essential for oocyte development and spermatogonial stem cell differentiation in zebrafish. Endocrinology. 163(2):
- King, A.C., Gut, M., Zenker, A.K. (2020) Shedding new light on early sex determination in zebrafish. Archives of toxicology. 94(12):4143-4158
- Li, M., Cao, J., Zhao, Y., Wu, P., Li, X., Khodaei, F., Han, Y., Wang, J. (2020) Fluoride impairs ovary development by affecting oogenesis and inducing oxidative stress and apoptosis in female zebrafish (Danio rerio). Chemosphere. 256:127105
- Romano, S., Kaufman, O.H., Marlow, F.L. (2020) Loss of dmrt1 restores female fates in the absence of cyp19a1a but not rbpms2a/b. Development (Cambridge, England). 147(18):
1 - 10 of 39
Show