Gene
myh9a
- ID
- ZDB-GENE-030131-5870
- Name
- myosin, heavy chain 9a, non-muscle
- Symbol
- myh9a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be located in cell cortex; cortical granule; and cytoskeleton. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
gyf11 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
gyf12 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
gyf13 | Allele with one deletion | Exon 1 | Unknown | CRISPR | |
sa2301 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa5350 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa15720 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa18153 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa20632 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33804 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33805 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-myh9a | (2) | |
CRISPR2-myh9a | (3) | |
CRISPR3-myh9a | (2) | |
CRISPR4-myh9a | (2) | |
CRISPR5-myh9a | Zebrafish Nomenclature Committee | |
MO1-myh9a | N/A | (4) |
MO2-myh9a | N/A | Müller et al., 2011 |
MO3-myh9a | N/A | Gutzman et al., 2015 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 17 | Alliance | Deafness, autosomal dominant 17 | 603622 |
MYH-9 related disease | Alliance | Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss | 155100 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
kidney disease | AB/EKW + MO1-myh9a | standard conditions | Anderson et al., 2015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BCY6 | InterPro | 1954 | |||||||
UniProtKB:A0A8M9PLW1 | InterPro | 997 | |||||||
UniProtKB:A0A8M1NEM1 | InterPro | 1961 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-215G15 | ZFIN Curated Data | |
Encodes | EST | fi22c04 | ||
Encodes | EST | fj85e11 | ||
Encodes | cDNA | MGC:66164 | ZFIN Curated Data | |
Encodes | cDNA | MGC:162029 | ZFIN Curated Data | |
Encodes | cDNA | MGC:165368 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001098177 (1) | 6842 nt | ||
Genomic | GenBank:CR925711 (1) | 200688 nt | ||
Polypeptide | UniProtKB:A0A8M1NEM1 (1) | 1961 aa |
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Rolfs, L.A., Falat, E.J., Gutzman, J.H. (2024) myh9b is a critical non-muscle myosin II encoding gene that interacts with myh9a and myh10 during zebrafish development in both compensatory and redundant pathways. G3 (Bethesda). 15(1):
- Ahuja, N., Ostwald, P., Gendernalik, A., Guzzolino, E., Pitto, L., Bark, D., Garrity, D.M. (2022) Myocardial Afterload Is a Key Biomechanical Regulator of Atrioventricular Myocyte Differentiation in Zebrafish. Journal of cardiovascular development and disease. 9(1):
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Guo, S., Meng, L., Liu, H., Yuan, L., Zhao, N., Ni, J., Zhang, Y., Ben, J., Li, Y.P., Ma, J. (2021) Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development. Theranostics. 11:4316-4334
- van Loon, A.P., Erofeev, I.S., Goryachev, A.B., Sagasti, A. (2021) Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells. Molecular biology of the cell. 32(16):1501-1513
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Hayes, M.N., McCarthy, K., Jin, A., Oliveira, M.L., Iyer, S., Garcia, S.P., Sindiri, S., Gryder, B., Motala, Z., Nielsen, G.P., Borg, J.P., van de Rijn, M., Malkin, D., Khan, J., Ignatius, M.S., Langenau, D.M. (2018) Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma. Cell Stem Cell. 22:414-427.e6
- Unal Eroglu, A., Mulligan, T.S., Zhang, L., White, D.T., Sengupta, S., Nie, C., Lu, N.Y., Qian, J., Xu, L., Pei, W., Burgess, S.M., Saxena, M.T., Mumm, J.S. (2018) Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration. Frontiers in cell and developmental biology. 6:88
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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