Gene
cfdp1
- ID
- ZDB-GENE-030131-5736
- Name
- craniofacial development protein 1
- Symbol
- cfdp1 Nomenclature History
- Previous Names
-
- fi15f05
- gaz
- rltpr
- si:dkey-6e12.6
- wu:fi15f05
- zgc:136405
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including bone mineralization; cerebellar granule cell differentiation; and neural retina development. Predicted to be located in kinetochore. Predicted to be part of Swr1 complex. Is expressed in several structures, including brain; fin bud; head; otic vesicle; and yolk syncytial layer. Orthologous to human CFDP1 (craniofacial development protein 1).
- Genome Resources
- Note
-
The genomic locus known as cfdp1 was originally misassigned as rltpr.
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150861 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| aa106 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| nub36 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| rk17 | Allele with one point mutation | Unknown | Unknown | not specified | |
| sa13566 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa29037 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32208 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cfdp1 | (2) | |
| CRISPR2-cfdp1 | Giardoglou et al., 2023 | |
| MO1-cfdp1 | N/A | Celauro et al., 2017 |
| MO2-cfdp1 | N/A | Giardoglou et al., 2023 |
| MO3-cfdp1 | N/A | Giardoglou et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BCNT-C domain | SWR1-complex protein 5/Craniofacial development protein 1/2 |
|---|---|---|---|---|
| UniProtKB:A3KPL8 | InterPro | 312 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6E12 | ZFIN Curated Data | |
| Encodes | EST | fi15f05 | ||
| Encodes | EST | IMAGE:7150861 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136405 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100035 (1) | 1741 nt | ||
| Genomic | GenBank:BX088593 (1) | 251217 nt | ||
| Polypeptide | UniProtKB:A3KPL8 (1) | 312 aa |
- Giardoglou, P., Deloukas, P., Dedoussis, G., Beis, D. (2023) Cfdp1 Is Essential for Cardiac Development and Function. Cells. 12(15):
- Itoh, T., Inoue, S., Sun, X., Kusuda, R., Hibi, M., Shimizu, T. (2021) Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(11):1618-1633
- Prozzillo, Y., Delle Monache, F., Ferreri, D., Cuticone, S., Dimitri, P., Messina, G. (2019) The True Story of Yeti, the "Abominable" Heterochromatic Gene of Drosophila melanogaster. Frontiers in Physiology. 10:1093
- Celauro, E., Carra, S., Rodriguez, A., Cotelli, F., Dimitri, P. (2017) Functional analysis of the cfdp1 gene in zebrafish provides evidence for its crucial role in craniofacial development and osteogenesis. Experimental cell research. 361(2):236-245
- Bae, Y.K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.I., and Hibi, M. (2009) Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Developmental Biology. 330(2):406-426
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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