Gene
traf6
- ID
- ZDB-GENE-030131-5735
- Name
- TNF receptor-associated factor 6
- Symbol
- traf6 Nomenclature History
- Previous Names
-
- fi15f02
- wu:fi15f02
- zgc:63704
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of DNA-templated transcription; and response to virus. Predicted to be located in cell cortex; lipid droplet; and nucleus. Predicted to be active in cytoplasm; cytoplasmic side of plasma membrane; and glutamatergic synapse. Is expressed in several structures, including bone tissue; central nervous system; heart; immune system; and liver. Orthologous to human TRAF6 (TNF receptor associated factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63704 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Aripaka et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-traf6 | Aripaka et al., 2019 | |
| MO1-traf6 | N/A | (3) |
| MO2-traf6 | N/A | Lefkopoulos et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MATH/TRAF domain | TNF receptor-associated factor 6, C3HC3D-type RING zinc finger | TNF receptor-associated factor 6, MATH domain | TNF receptor-associated factor TRAF, metazoa | TRAF1-6, MATH domain | TRAF-like | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6IWL4 | InterPro PDB | 542 | |||||||||||
| UniProtKB:A0AB32TYI6 | InterPro | 542 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-56P7 | ZFIN Curated Data | |
| Encodes | EST | fi15f02 | ||
| Encodes | cDNA | MGC:63704 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198210 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198214 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044752 (1) | 1733 nt | ||
| Genomic | GenBank:AL929208 (1) | 189608 nt | ||
| Polypeptide | UniProtKB:A0AB32TYI6 (1) | 542 aa |
- Weng, P., Lan, M., Zhang, H., Fan, H., Wang, X., Ran, C., Yue, Z., Hu, J., Xu, A., Huang, S. (2024) Both IRAK3 and IRAK1 Activate the MyD88-TRAF6 Pathway in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 213(3):362-372
- Zhang, C., Zhao, Z., Jia, Y.J., Zhang, P.Q., Sun, Y., Zhou, Y.C., Wang, G.X., Zhu, B. (2023) Rationally Designed Self-Assembling Nanovaccines Elicit Robust Mucosal and Systemic Immunity against Rhabdovirus. ACS applied materials & interfaces. 16(1):228-244
- Zhong, Y.T., Liao, H.B., Ye, Z.Q., Jiang, H.S., Li, J.X., Ke, L.M., Hua, J.Y., Wei, B., Wu, X., Cui, L. (2023) Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. Journal of orthopaedic translation. 40:132146132-146
- Wei, Y., Du, X., Guo, Y., Chang, M., Deng, B., Liu, J., Cao, J. (2022) Elucidation of physicochemical properties of polysaccharides extracted from Cordyceps militaris fruiting bodies with different drying treatments and their effects on ulcerative colitis in zebrafish. Frontiers in nutrition. 9:980357
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Zhang, X.H., Zhou, C.C., Li, C.Y., Hua, Y., Li, K., Wei, P., He, M.F. (2021) Isoliquiritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 83:153469
- Zhu, J., Li, X., Sun, X., Zhou, Z., Cai, X., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6. Journal of immunology (Baltimore, Md. : 1950). 207(10):2570-2580
- Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9
- Liu, R., Hu, X., Lü, A., Song, Y., Lian, Z., Sun, J., Sung, Y.Y. (2020) Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Zebrafish. 17:91-103
- Liyanage, T.D., Nikapitiya, C., Lee, J., De Zoysa, M. (2020) Molecular insight into regulation of miRNA in the spleen of zebrafish (Danio rerio) upon pathogenic Streptococcus parauberis infection. Fish & shellfish immunology. 106:898-909
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