Gene

rac1a

ID
ZDB-GENE-030131-5415
Name
Rac family small GTPase 1a
Symbol
rac1a Nomenclature History
Previous Names
  • rac1
  • wu:fd16e02
  • zgc:55823
  • zgc:86934
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la018021TgTransgenic insertionUnknownUnknownDNA
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-rac1a
    Reijnders et al., 2017
    CRISPR2-rac1a
      Doan et al., 2025
      MO1-rac1aN/A (4)
      1 - 3 of 3
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      Human Disease
      Associated With rac1a Human Ortholog
      Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
      autosomal dominant intellectual developmental disorder 48 Alliance Intellectual developmental disorder, autosomal dominant 48 617751
      1 - 1 of 1
      Associated With rac1a Via Experimental Models
      No data available
      Gene Ontology
      Protein Domains
      Domain, Family, and Site Summary
      Type InterPro ID Name
      Domain IPR005225 Small GTP-binding domain
      Family IPR001806 Small GTPase
      Family IPR003578 Small GTPase Rho
      Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
      1 - 4 of 4
      Domain Details Per Protein
      Protein Additional Resources Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding domain
      UniProtKB:Q7ZSZ9 InterPro 192
      1 - 1 of 1
      Transcripts
      Genome Browsers
      Genome Build: GRCz11Chromosome: 12
      Type Name Annotation Method Has Havana Data Length (nt) Analysis
      mRNA rac1a-201 (1) Ensembl 1,893 nt
      ncRNA rac1a-003 (1) Ensembl 798 nt
      1 - 2 of 2
      Interactions and Pathways
      No data available
      Antibodies
      Name Type Antigen Genes Isotype Host Organism Assay Source Citations
      Ab1-rac1 polyclonal IgG Rabbit
      • IHC
      • WB
      Santa Cruz Biotechnology, Inc.
      3
      Ab2-rac1 monoclonal IgG2b Mouse
      Millipore
      3
      1 - 2 of 2
      Plasmids
      Constructs
      1 - 10 of 11
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      Marker Relationships
      Relationship Marker Type Marker Accession Numbers Citations
      Contained inBACCH73-318L24ZFIN Curated Data
      EncodesESTfd16e02
      EncodescDNAMGC:55823ZFIN Curated Data
      EncodescDNAMGC:55917ZFIN Curated Data
      EncodescDNAMGC:86934ZFIN Curated Data
      1 - 5 of 5
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      Sequences
      Orthology
      Comparative Orthology
      Alliance
      Gene Tree
      Ensembl
      Species Symbol Chromosome Accession # Evidence
      HumanRAC17
      Conserved genome location (synteny) (1)
      Amino acid sequence comparison (1)
      MouseRac15
      Amino acid sequence comparison (1)
      Citations
      1 - 10 of 45
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