Gene
gabarapa
- ID
- ZDB-GENE-030131-5174
- Name
- GABA(A) receptor-associated protein a
- Symbol
- gabarapa Nomenclature History
- Previous Names
-
- gabarap
- mg:bb02b03
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GABA receptor binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within brain development. Predicted to be located in autophagosome; endomembrane system; and membrane. Predicted to be active in autophagosome membrane. Is expressed in central nervous system; eye; and heart. Orthologous to human GABARAP (GABA type A receptor-associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Komoike et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024881Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-gabarapa | N/A | Komoike et al., 2010 |
| MO2-gabarapa | N/A | Komoike et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Autophagy protein Atg8 ubiquitin-like | Ubiquitin-like domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q6NZZ7 | InterPro | 163 | ||
| UniProtKB:Q6PSS4 | InterPro | 122 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gabarapa-201
(1)
|
Ensembl | 1,315 nt | ||
| ncRNA |
gabarapa-002
(1)
|
Ensembl | 706 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gabarap | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(CMV:EGFP-gabarapa) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-114C12 | ZFIN Curated Data | |
| Encodes | EST | bb02b03 | ||
| Encodes | EST | IMAGE:6997688 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013260 (1) | 1374 nt | ||
| Genomic | GenBank:AL928875 (2) | 158038 nt | ||
| Polypeptide | UniProtKB:Q6NZZ7 (1) | 163 aa |
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Liu, D., Jiang, Z., Deng, L., Li, H., Jiang, H. (2023) Identification of an α-l-iduronidase (IDUA) M1T mutation in a Chinese family with autosomal recessive mucopolysaccharidosis I. Annals of the New York Academy of Sciences. 1526(1):114-125
- Swaminathan, A., Gliksberg, M., Anbalagan, S., Wigoda, N., Levkowitz, G. (2023) Stress resilience is established during development and is regulated by complement factors. Cell Reports. 42:111973111973
- Widelski, J., Kasica, N., Maciąg, M., Luca, S.V., Budzyńska, B., Fondai, D., Podlasz, P., Skalicka-Woźniak, K. (2023) Simple Coumarins from Peucedanum luxurians Fruits: Evaluation of Anxiolytic Activity and Influence on Gene Expression Related to Anxiety in Zebrafish Model. International Journal of Molecular Sciences. 24(10):
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Wang, H., Qiu, T.X., Lu, J.F., Liu, H.W., Hu, L., Liu, L., Chen, J. (2021) Potential aquatic environmental risks of trifloxystrobin: Enhancement of virus susceptibility in zebrafish through initiation of autophagy. Zoological research. 42:339-349
- Bello-Perez, M., Pereiro, P., Coll, J., Novoa, B., Perez, L., Falco, A. (2020) Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol. Scientific Reports. 10:566
- Enomoto, H., Mittal, N., Inomata, T., Arimura, T., Izumi, T., Kimura, A., Fukuda, K., Makino, S. (2020) Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. Cardiovascular research. 117(4):1118-1131
- Sendra, M., Pereiro, P., Yeste, M.P., Mercado, L., Figueras, A., Novoa, B. (2020) Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism. Environmental pollution (Barking, Essex : 1987). 268:115769
- Librán-Pérez, M., Pereiro, P., Figueras, A., Novoa, B. (2019) Antiviral activity of palmitic acid via autophagic flux inhibition in zebrafish (Danio rerio). Fish & shellfish immunology. 95:595-605
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