Gene
parp1
- ID
- ZDB-GENE-030131-3955
- Name
- poly (ADP-ribose) polymerase 1
- Symbol
- parp1 Nomenclature History
- Previous Names
-
- si:dkey-206f10.3
- wu:fc60f12
- zgc:110092
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Enables NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Involved in DNA repair and regulation of circadian sleep/wake cycle, sleep. Predicted to be located in chromatin. Predicted to be active in nuclear replication fork; nucleolus; and site of DNA damage. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la013903Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa11149 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa12069 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa23796 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa31048 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | ADP-ribosyltransferase diphtheria toxin-like | BRCT domain | BRCT domain superfamily | PADR1, C-terminal domain superfamily | PARP1-like, PADR1 domain, N-terminal helical subdomain | PARP1-like, PADR1 domain, zinc ribbon fold | Poly [ADP-ribose] polymerase | Poly(ADP-ribose) polymerase, catalytic domain | Poly(ADP-ribose) polymerase, regulatory domain | Poly(ADP-ribose) polymerase, regulatory domain superfamily | WGR domain | WGR domain superfamily | Zinc finger, PARP-type | Zinc finger, PARP-type superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8N1TQ38 | InterPro | 1013 | ||||||||||||||
UniProtKB:Q5RHR0 | InterPro | 1013 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-206F10 | ZFIN Curated Data | |
Encodes | EST | fc60f12 | ||
Encodes | EST | IMAGE:7145352 | Thisse et al., 2004 | |
Encodes | EST | IMAGE:7149907 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:110092 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001044942 (1) | 3802 nt | ||
Genomic | GenBank:BX470188 (1) | 167082 nt | ||
Polypeptide | UniProtKB:A0A8N1TQ38 (1) | 1013 aa |
- Carrara, M., Gaillard, A.L., Brion, A., Duvernois-Berthet, E., Giovannangeli, C., Concordet, J.P., Pézeron, G. (2025) Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish. Scientific Reports. 15:48864886
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Cabas, I., Martínez-Vicente, I., Armistead, J., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt, M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2021) NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biology. 19:e3001455
- Tsikarishvili, S., Karapetian, M., Kulikova, N., Zaalishvili, G. (2021) PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos. Biochemical and Biophysical Research Communications. 550:166-170
- Wang, Y., Yang, L. (2021) Genomic Evidence for Convergent Molecular Adaptation in Electric Fishes. Genome biology and evolution. 13(3):
- Zada, D., Sela, Y., Matosevich, N., Monsonego, A., Lerer-Goldshtein, T., Nir, Y., Appelbaum, L. (2021) Parp1 promotes sleep, which enhances DNA repair in neurons. Molecular Cell. 81(24):4979-4993.e7
- Zhang, L., Chen, C., Fu, J., Lilley, B., Berlinicke, C., Hansen, B., Ding, D., Wang, G., Wang, T., Shou, D., Ye, Y., Mulligan, T., Emmerich, K., Saxena, M.T., Hall, K.R., Sharrock, A.V., Brandon, C., Park, H., Kam, T.I., Dawson, V.L., Dawson, T.M., Shim, J.S., Hanes, J., Ji, H., Liu, J.O., Qian, J., Ackerley, D.F., Rohrer, B., Zack, D.J., Mumm, J.S. (2021) Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. eLIFE. 10:
- Jing, C.B., Fu, C., Prutsch, N., Wang, M., He, S., Look, A.T. (2020) Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. Leukemia. 34(11):2992-3006
- Costa, S.R., Velasques, R.R., Hoff, M.L.M., Souza, M.M., Sandrini, J.Z. (2019) Characterization of different DNA repair pathways in hepatic cells of Zebrafish (Danio rerio). DNA repair. 83:102695
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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