Gene
chrng
- ID
- ZDB-GENE-030131-3805
- Name
- cholinergic receptor, nicotinic, gamma
- Symbol
- chrng Nomenclature History
- Previous Names
-
- chrngl
- AChr gamma (1)
- wu:fc54e06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Contributes to acetylcholine receptor activity. Acts upstream of or within cellular response to acetylcholine and cholinergic synaptic transmission. Part of acetylcholine-gated channel complex. Is expressed in musculature system. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
contractures, pterygia, and spondylocarpotarsal fusion syndrome | Alliance | Escobar syndrome | 265000 |
contractures, pterygia, and spondylocarpotarsal fusion syndrome | Alliance | Multiple pterygium syndrome, lethal type | 253290 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
Family | IPR002394 | Nicotinic acetylcholine receptor |
Family | IPR006201 | Neurotransmitter-gated ion-channel |
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Domain Details Per Protein
Protein | Additional Resources | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:G1FMP9 | InterPro | 540 | ||||||||
UniProtKB:E7F9V1 | InterPro | 540 |
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- Genome Browsers
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-chrne,chrng | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
- Campanari, M.L., Marian, A., Ciura, S., Kabashi, E. (2021) TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish. Cells. 10(2):
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
- Amin, M.R., Ahmed, K.T., Ali, D.W. (2020) Early Exposure to THC Alters M-Cell Development in Zebrafish Embryos. Biomedicines. 8(1):
- Bourefis, A.R., Campanari, M.L., Buee-Scherrer, V., Kabashi, E. (2020) Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS. Neurobiology of disease. 142:104935
- Zempo, B., Yamamoto, Y., Williams, T., Ono, F. (2020) Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. Science advances. 6:eaax8382
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2019) Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evolutionary Biology. 19:38
- Ahmed, K.T., Ali, D.W. (2016) Nicotinic acetylcholine receptors (nAChRs) at zebrafish red and white muscle show different properties during development. Developmental Neurobiology. 76(8):916-36
- Menelaou, E., Udvadia, A.J., Tanguay, R.L., Svoboda, K.R. (2014) Activation of α2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. The European journal of neuroscience. 40(1):2225-2240
- Park, J.Y., Mott, M., Williams, T., Ikeda, H., Wen, H., Linhoff, M., Ono, F. (2014) A Single Mutation in the Acetylcholine Receptor δ-Subunit Causes Distinct Effects in Two Types of Neuromuscular Synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:10211-10218
- Ho, N.Y., Yang, L., Legradi, J., Armant, O., Takamiya, M., Rastegar, S., and Strähle, U. (2013) Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environmental science & technology. 47(7):3316-25
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