Gene

ptena

ID
ZDB-GENE-030131-3776
Name
phosphatase and tensin homolog A
Symbol
ptena Nomenclature History
Previous Names
  • wu:fc52g04
  • zgc:73086
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Enables lipid phosphatase activity. Acts upstream of or within several processes, including hepatocyte proliferation; lifelong otolith mineralization; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including nervous system; oocyte; otic vesicle; presumptive neural retina; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hu1864Allele with one point mutationUnknownPremature StopENU
ihb535Allele with one delinsUnknownUnknownnot specified
ihb536Allele with one deletionUnknownUnknownCRISPR
la013071TgTransgenic insertionUnknownUnknownDNA
sa12727Allele with one point mutationUnknownSplice SiteENU
sa39161Allele with one point mutationUnknownPremature StopENU
sa42927Allele with one point mutationUnknownPremature StopENU
zf3641unknownUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With ptena Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
Bannayan-Riley-Ruvalcaba syndrome Alliance Lhermitte-Duclos disease 158350
macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
prostate cancer Alliance Prostate cancer, somatic 176807
{Glioma susceptibility 2} 613028
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Associated With ptena Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR014020 Tensin phosphatase, C2 domain
Domain IPR029023 Tensin-type phosphatase domain
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Domain Details Per Protein
Protein Additional Resources Length Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN C2 domain superfamily Dual-specificity lipid and protein phosphatase Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTEN, phosphatase domain Tensin phosphatase, C2 domain Tensin-type phosphatase domain Tyrosine-specific protein phosphatases domain
UniProtKB:Q6TGR7 InterPro 431
UniProtKB:A0A8M1PHN1 InterPro 454
UniProtKB:Q6PC66 InterPro 452
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ptena-201 (1) Ensembl 1,626 nt
mRNA ptena-202 (1) Ensembl 1,341 nt
mRNA ptena-203 (1) Ensembl 2,993 nt
mRNA ptena-204 (1) Ensembl 1,302 nt
mRNA ptena-206 (1) Ensembl 1,626 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptena monoclonal IgG Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
9
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Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-243K10ZFIN Curated Data
EncodesESTfc52g04
EncodescDNAMGC:73086ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanPTEN10
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Functional complementation (1)
Phylogenetic tree (1)
MousePten19
Amino acid sequence comparison (2)
Conserved genome location (synteny) (1)
Phylogenetic tree (1)
Citations
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