Gene
ptena
- ID
- ZDB-GENE-030131-3776
- Name
- phosphatase and tensin homolog A
- Symbol
- ptena Nomenclature History
- Previous Names
-
- wu:fc52g04
- zgc:73086
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Enables lipid phosphatase activity. Acts upstream of or within several processes, including hepatocyte proliferation; lifelong otolith mineralization; and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic density. Predicted to be active in several cellular components, including cytosol; nucleus; and plasma membrane. Is expressed in several structures, including nervous system; oocyte; otic vesicle; presumptive neural retina; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73086 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hu1864 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
ihb535 | Allele with one delins | Unknown | Unknown | not specified | |
ihb536 | Allele with one deletion | Unknown | Unknown | CRISPR | |
la013071Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa12727 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa39161 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa42927 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
zf3641 | unknown | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-ptena | (4) | |
CRISPR2-ptena | Zebrafish Nomenclature Committee | |
CRISPR3-ptena | Luo et al., 2021 | |
CRISPR4-ptena | Suresh et al., 2022 | |
MO1-ptena | N/A | (4) |
MO2-ptena | N/A | Croushore et al., 2005 |
MO3-ptena | N/A | (2) |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Bannayan-Riley-Ruvalcaba syndrome | Alliance | Cowden syndrome 1 | 158350 |
Bannayan-Riley-Ruvalcaba syndrome | Alliance | Lhermitte-Duclos disease | 158350 |
macrocephaly-autism syndrome | Alliance | Macrocephaly/autism syndrome | 605309 |
prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
{Glioma susceptibility 2} | 613028 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
Domain | IPR014020 | Tensin phosphatase, C2 domain |
Domain | IPR029023 | Tensin-type phosphatase domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | C2 domain superfamily | Dual-specificity lipid and protein phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTEN, phosphatase domain | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6TGR7 | InterPro | 431 | ||||||||||
UniProtKB:A0A8M1PHN1 | InterPro | 454 | ||||||||||
UniProtKB:Q6PC66 | InterPro | 452 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-ptena | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
9 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-243K10 | ZFIN Curated Data | |
Encodes | EST | fc52g04 | ||
Encodes | cDNA | MGC:73086 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200708 (1) | 1635 nt | ||
Genomic | GenBank:BX511087 (1) | 184012 nt | ||
Polypeptide | UniProtKB:A0A8M1PHN1 (1) | 454 aa |
- Chen, X., Shen, Y., Song, Z., Wang, X., Yao, H., Cai, Y., Zhao, Z., Hu, B. (2024) microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation. Journal of genetics and genomics = Yi chuan xue bao. 51(9):911-921
- Lumaquin-Yin, D., Montal, E., Johns, E., Baggiolini, A., Huang, T.H., Ma, Y., LaPlante, C., Suresh, S., Studer, L., White, R.M. (2023) Lipid droplets are a metabolic vulnerability in melanoma. Nature communications. 14:31923192
- Tagore, M., Hergenreder, E., Perlee, S.C., Cruz, N.M., Menocal, L., Suresh, S., Chan, E., Baron, M., Melendez, S., Dave, A., Chatila, W.K., Nsengimana, J., Koche, R.P., Hollmann, T.J., Ideker, T., Studer, L., Schietinger, A., White, R.M. (2023) GABA regulates electrical activity and tumor initiation in melanoma. Cancer discovery. 13(10):2270-2291
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Suresh, S., Rabbie, R., Garg, M., Lumaquin, D., Huang, T.H., Montal, E., Ma, Y., Cruz, N.M., Tang, X., Nsengimana, J., Newton-Bishop, J., Hunter, M.V., Zhu, Y., Chen, K., de Stanchina, E., Adams, D.J., White, R.M. (2022) Identifying the transcriptional drivers of metastasis embedded within localized melanoma. Cancer discovery. 13(1):194-215
- Baggiolini, A., Callahan, S.J., Montal, E., Weiss, J.M., Trieu, T., Tagore, M.M., Tischfield, S.E., Walsh, R.M., Suresh, S., Fan, Y., Campbell, N.R., Perlee, S.C., Saurat, N., Hunter, M.V., Simon-Vermot, T., Huang, T.H., Ma, Y., Hollmann, T., Tickoo, S.K., Taylor, B.S., Khurana, E., Koche, R.P., Studer, L., White, R.M. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science (New York, N.Y.). 373:eabc1048
- Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755
- He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729
- Luo, J., Lu, C., Feng, M., Dai, L., Wang, M., Qiu, Y., Zheng, H., Liu, Y., Li, L., Tang, B., Xu, C., Wang, Y., Yang, X. (2021) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Journal of experimental & clinical cancer research : CR. 40:262
- Qu, X., Liao, M., Liu, W., Cai, Y., Yi, Q., Long, J., Tan, L., Deng, Y., Deng, H., Chen, X. (2021) Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish. International Journal of Molecular Sciences. 22(13):
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