Gene
slc2a1a
- ID
- ZDB-GENE-030131-3158
- Name
- solute carrier family 2 member 1a
- Symbol
- slc2a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables D-glucose transmembrane transporter activity. Acts upstream of or within several processes, including D-glucose import; endothelial cell development; and vasculature development. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including cardiovascular system; intermediate mesoderm; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fcc27Gt | Transgenic insertion | Unknown | Splicing Variant | DNA | |
| la028504Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| s3034 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa43972 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43973 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zju134 | Allele with one delins | Exon 4 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dystonia 9 | Alliance | Dystonia 9 | 601042 |
| glucose transporter type 1 deficiency syndrome 1 | Alliance | GLUT1 deficiency syndrome 1, infantile onset, severe | 606777 |
| glucose transporter type 1 deficiency syndrome 2 | Alliance | GLUT1 deficiency syndrome 2, childhood onset | 612126 |
| obsolete idiopathic generalized epilepsy 12 | Alliance | {Epilepsy, idiopathic generalized, susceptibility to, 12} | 614847 |
| Stomatin-deficient cryohydrocytosis with neurologic defects | 608885 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glucose transporter GLUT | Major facilitator, sugar transporter-like | Major facilitator superfamily domain | MFS transporter superfamily | Sugar/inositol transporter | Sugar transporter, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q285P3 | InterPro | 488 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc2a1a-201
(1)
|
Ensembl | 1,792 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-slc2a1a | polyclonal | Rabbit |
|
Dako North America, Inc.
|
4 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(slc2a1a:EGFP) |
|
| 1 | Quiñonez-Silvero et al., 2019 | |
| Tg(slc2a1a:mCherry) |
|
| 1 | (9) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-35J18 | ||
| Contains | SNP | rs3729253 | ZFIN Curated Data | |
| Encodes | EST | fc29a02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039808 (1) | 1743 nt | ||
| Genomic | GenBank:AL954133 (1) | 206373 nt | ||
| Polypeptide | UniProtKB:Q285P3 (1) | 488 aa |
- Sebo, D.J., Ali, I., Fetsko, A.R., Trimbach, A.A., Taylor, M.R. (2025) Activation of Wnt/β-catenin in neural progenitor cells regulates blood-brain barrier development and promotes neuroinflammation. Scientific Reports. 15:34963496
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Ribeiro, T., Reis, M., Vasconcelos, V., Urbatzka, R. (2024) Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics. Scientific Reports. 14:3214232142
- Wang, Z., Zhu, C., Sun, X., Deng, H., Liu, W., Jia, S., Bai, Y., Xiao, W., Liu, X. (2024) Spring viremia of carp virus infection induces hypoxia response in zebrafish by stabilizing hif1α. Journal of virology. :e0149124e0149124
- Zhu, X., Zhang, D., Wang, Y., Wang, C., Liu, X., Niu, Y. (2024) Study on the signaling pathways involved in the anti-hyperglycemic effect of raspberry ketone on zebrafish using integrative transcriptome and metabolome analyses. Food & function. 15(18):9457-9470
- Antomagesh, F., Jayakumar Rajeswari, J., Vijayan, M.M. (2023) Chronic cortisol elevation restricts glucose uptake but not insulin responsiveness in zebrafish skeletal muscle. General and comparative endocrinology. 336:114231
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257
- Rosa, I.F., Peçanha, A.P.B., Carvalho, T.R.B., Alexandre, L.S., Ferreira, V.G., Doretto, L.B., Souza, B.M., Nakajima, R.T., da Silva, P., Barbosa, A.P., Gomes-de-Pontes, L., Bomfim, C.G., Machado-Santelli, G.M., Condino-Neto, A., Guzzo, C.R., Peron, J.P.S., Andrade-Silva, M., Câmara, N.O.S., Garnique, A.M.B., Medeiros, R.J., Ferraris, F.K., Barcellos, L.J.G., Correia-Junior, J.D., Galindo-Villegas, J., Machado, M.F.R., Castoldi, A., Oliveira, S.L., Costa, C.C., Belo, M.A.A., Galdino, G., Sgro, G.G., Bueno, N.F., Eto, S.F., Veras, F.P., Fernandes, B.H.V., Sanches, P.R.S., Cilli, E.M., Malafaia, G., Nóbrega, R.H., Garcez, A.S., Carrilho, E., Charlie-Silva, I. (2023) Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model. International Journal of Molecular Sciences. 24(7):
- Tang, Z., Wang, K., Lo, L., Chen, J. (2023) Tg(Δ113p53:cmyc) Transgene Upregulates glut1 Expression to Promote Zebrafish Heart Regeneration. Journal of cardiovascular development and disease. 10(6):
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