Gene
sp5l
- ID
- ZDB-GENE-030131-2981
- Name
- Sp5 transcription factor-like
- Symbol
- sp5l Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic organ development; mesoderm formation; and post-anal tail morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including forerunner cell group; mesoderm; nervous system; neural plate; and notochord. Orthologous to human SP5 (Sp5 transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb577 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tan et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
fh241 | Allele with one point mutation | Unknown | Unknown | ENU | |
mpn421Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
sa3223 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa11869 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa43999 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sp5l_unrecovered | Allele with one point mutation | Unknown | Unknown | ENU | |
x70 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-sp5l | Tan et al., 2022 | |
MO1-sp5l | N/A | Zhao et al., 2003 |
MO2-sp5l | N/A | (6) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
---|---|---|---|---|
UniProtKB:Q7T2W1 | InterPro | 357 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Encodes | EST | cb577 | ||
Encodes | EST | fc23b01 | ||
Encodes | cDNA | MGC:136509 | ZFIN Curated Data |
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No data available
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Cark, O., Katkat, E., Aydogdu, I., Iscan, E., Oktay, Y., Ozhan, G. (2024) tubg1 Somatic Mutants Show Tubulinopathy-Associated Neurodevelopmental Phenotypes in a Zebrafish Model. Molecular neurobiology. :
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Xu, Y., Liu, J., Tian, Y., Wang, Z., Song, Z., Li, K., Zhang, S., Zhao, H. (2022) Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging. International Journal of Molecular Sciences. 23(19):
- Ozalp, O., Cark, O., Azbazdar, Y., Haykir, B., Cucun, G., Kucukaylak, I., Alkan-Yesilyurt, G., Sezgin, E., Ozhan, G. (2021) Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis. Biomolecules. 11(1):
- Wang, B., Rong, X., Zhou, Y., Liu, Y., Sun, J., Zhao, B., Deng, B., Lu, L., Lu, L., Li, Y., Zhou, J. (2021) Eukaryotic initiation factor 4A3 inhibits Wnt/β-catenin signaling and regulates axis formation in zebrafish embryos. Development (Cambridge, England). 148(9):
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Wint, J.M., Sirotkin, H.I. (2020) Lrrk2 modulation of Wnt signaling during zebrafish development. Journal of neuroscience research. 98(10):1831-1842
- Azbazdar, Y., Ozalp, O., Sezgin, E., Veerapathiran, S., Duncan, A.L., Sansom, M.S.P., Eggeling, C., Wohland, T., Karaca, E., Ozhan, G. (2019) More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Frontiers in cell and developmental biology. 7:281
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