Gene
c3b.1
- ID
- ZDB-GENE-030131-2211
- Name
- complement component c3b, tandem duplicate 1
- Symbol
- c3b.1 Nomenclature History
- Previous Names
-
- c3.7 (1)
- si:dkey-21e7.2
- wu:fb99g02
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in nervous system development. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular space. Is expressed in brain; gill; liver; pleuroperitoneal region; and post-vent region. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24189 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30732 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31073 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32404 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37528 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37529 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43860 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45772 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-c3b | N/A | Forn-Cuní et al., 2014 |
| MO2-c3b | N/A | Forn-Cuní et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 9 | Alliance | {Macular degeneration, age-related, 9} | 611378 |
| complement component 3 deficiency | Alliance | C3 deficiency | 613779 |
| {Hemolytic uremic syndrome, atypical, susceptibility to, 5} | 612925 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Complement C3/4/5, macroglobulin domain MG1 | Complement component 3, CUB domain, second segment | Immunoglobulin E-set | Immunoglobulin-like fold | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5PMP6 | InterPro | 1680 | ||||||||||||||||||||
| UniProtKB:A0A8M3B5N7 | InterPro | 1768 | ||||||||||||||||||||
| UniProtKB:A0A8M9PDW4 | InterPro | 1719 | ||||||||||||||||||||
| UniProtKB:A0A8M2BLB5 | InterPro | 1746 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-140F21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-21E7 | ZFIN Curated Data | |
| Encodes | EST | fb99g02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100013 (1) | 5043 nt | ||
| Genomic | GenBank:BX649330 (2) | 163964 nt | ||
| Polypeptide | UniProtKB:A0A8M3B5N7 (1) | 1768 aa |
- Gaillard, A.L., Mohamad, T., Quan, F.B., de Cian, A., Mosimann, C., Tostivint, H., Pézeron, G. (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology. 496:36-51
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Houseright, R.A., Rosowski, E.E., Lam, P.Y., Tauzin, S.J.M., Mulvaney, O., Dewey, C.N., Huttenlocher, A. (2020) Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Scientific Reports. 10:15716
- Qin, C., Xie, Y., Wang, Y., Li, S., Ran, C., He, S., Zhou, Z. (2018) Impact of Lactobacillus casei BL23 on the Host Transcriptome, Growth and Disease Resistance in Larval Zebrafish.. Frontiers in Physiology. 9:1245
- Zhang, Q.F., Li, Y.W., Liu, Z.H., Chen, Q.L. (2016) Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae. Aquatic toxicology (Amsterdam, Netherlands). 181:76-85
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Forn-Cuní, G., Reis, E.S., Dios, S., Posada, D., Lambris, J.D., Figueras, A., Novoa, B. (2014) The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory Activity. PLoS One. 9:e99673
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