Gene
prdm1a
- ID
- ZDB-GENE-030131-2193
- Name
- PR domain containing 1a, with ZNF domain
- Symbol
- prdm1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including negative regulation of macromolecule biosynthetic process; positive regulation of cell differentiation; and skeletal system morphogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including ectoderm; fin bud; gut; head; and mesoderm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 60 figures from 33 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136589 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 45 figures from 22 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| m805 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| nl3 | Allele with one point mutation | Unknown | Unknown | ENU | |
| prdm1a_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| sa6407 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9796 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22750 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tp39 | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prdm1a | Emmerich et al., 2023 | |
| CRISPR2-prdm1a | Emmerich et al., 2023 | |
| CRISPR3-prdm1a | Emmerich et al., 2023 | |
| CRISPR4-prdm1a | Emmerich et al., 2023 | |
| MO1-prdm1a | N/A | (4) |
| MO2-prdm1a | N/A | (12) |
| MO3-prdm1a | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PRDM1, PR/SET domain | PR domain zinc finger protein 1 | SET domain | SET domain superfamily | Zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q68EH4 | InterPro | 776 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prdm1a-201
(1)
|
Ensembl | 3,694 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-60prdm1a:EGFP) |
|
| 1 | (5) | |
| Tg(hsp70l:prdm1a) |
|
| 1 | (3) | |
| TgPAC(prdm1a:EGFP) |
|
| 2 | (17) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-11F5 | ||
| Encodes | EST | fb99c12 | ||
| Encodes | EST | IMAGE:7136589 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:91885 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199515 (1) | 3700 nt | ||
| Genomic | GenBank:AL928573 (1) | 244471 nt | ||
| Polypeptide | UniProtKB:Q68EH4 (1) | 776 aa |
- Aranda-Martínez, P., Sayed, R.K.A., Fernández-Martínez, J., Ramírez-Casas, Y., Yang, Y., Escames, G., Acuña-Castroviejo, D. (2024) Zebrafish as a Human Muscle Model for Studying Age-Dependent Sarcopenia and Frailty. International Journal of Molecular Sciences. 25(11):
- Truong, B.T., Shull, L.C., Zepeda, B.J., Lencer, E., Artinger, K.B. (2024) Human split hand/foot variants are not as functional as wildtype human PRDM1 in the rescue of craniofacial defects. Birth defects research. 116:e2327e2327
- Yong, P., Zhang, Z., Du, S. (2024) Ectopic expression of Myomaker and Myomixer in slow muscle cells induces slow muscle fusion and myofiber death. Journal of genetics and genomics = Yi chuan xue bao. 51(11):1187-1203
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Lencer, E., Rains, A., Binne, E., Prekeris, R., Artinger, K. (2023) Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish. Development (Cambridge, England). 150(14):
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Truong, B.T., Shull, L.C., Lencer, E., Bend, E.G., Field, M., Blue, E.E., Bamshad, M.J., Skinner, C., Everman, D., Schwartz, C.E., Flanagan-Steet, H., Artinger, K.B. (2023) PRDM1 DNA-binding zinc finger domain is required for normal limb development and is disrupted in split hand/foot malformation. Disease models & mechanisms. 16(4):
- Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
- Feng, G., Sun, Y. (2022) The Polycomb group gene rnf2 is essential for central and enteric neural system development in zebrafish. Frontiers in neuroscience. 16:960149
- Mendieta-Serrano, M.A., Dhar, S., Ng, B.H., Narayanan, R., Lee, J.J.Y., Ong, H.T., Toh, P.J.Y., Röllin, A., Roy, S., Saunders, T.E. (2022) Slow muscles guide fast myocyte fusion to ensure robust myotome formation despite the high spatiotemporal stochasticity of fusion events. Developmental Cell. 57(17):2095-2110.e5
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