Gene
ace
- ID
- ZDB-GENE-030131-1826
- Name
- angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Symbol
- ace Nomenclature History
- Previous Names
-
- fb81h03
- si:ch211-124e16.1
- wu:fb81h03 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable metallopeptidase activity and peptidyl-dipeptidase activity. Acts upstream of or within regulation of intestinal epithelial structure maintenance. Predicted to be located in membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including adaxial cell; digestive system; eye; heart; and kidney. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); heart valve disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Wei et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ouc1004 | Allele with one delins | Exon 8 | Unknown | CRISPR | |
| sa9141 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12049 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17717 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19024 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41956 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 6 of 6
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ace | Wei et al., 2024 | |
| MO1-ace | N/A | Kitambi et al., 2009 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001548 | Peptidase M2, peptidyl-dipeptidase A |
1 - 1 of 1
Domain Details Per Protein
| Protein | Additional Resources | Length | Peptidase M2, peptidyl-dipeptidase A |
|---|---|---|---|
| UniProtKB:E7FFA5 | InterPro | 1324 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-124E16 | ZFIN Curated Data | |
| Contained in | BAC | CH211-271E19 | ZFIN Curated Data | |
| Encodes | EST | fb64c02 | Rauch et al., 2003 | |
| Encodes | EST | fb81h03 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_689244 (1) | 4266 nt | ||
| Genomic | GenBank:CU459092 (1) | 147841 nt | ||
| Polypeptide | UniProtKB:E7FFA5 (1) | 1324 aa |
- Wei, M., Yu, Q., Li, E., Zhao, Y., Sun, C., Li, H., Liu, Z., Ji, G. (2024) Ace Deficiency Induces Intestinal Inflammation in Zebrafish. International Journal of Molecular Sciences. 25(11):
- Horzmann, K.A., Lin, L.F., Taslakjian, B., Yuan, C., Freeman, J.L. (2022) Anxiety-related behavior and associated brain transcriptome and epigenome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Chemosphere. 308(Pt 3):136431
- Cahill, T., da Silveira, W.A., Renaud, L., Williamson, T., Wang, H., Chung, D., Overton, I., Chan, S.S.L., Hardiman, G. (2021) Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cells. 10(4):
- Kim, G.J., Melgoza, A., Jiang, F., Guo, S. (2021) The effect of renin-angiotensin-aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19. Scientific Reports. 11:23670
- Kim, G.J., Mo, H., Liu, H., Wu, Z., Chen, S., Zheng, J., Zhao, X., Nucum, D., Shortland, J., Peng, L., Elepano, M., Tang, B., Olson, S., Paras, N., Li, H., Renslo, A.R., Arkin, M.R., Huang, B., Lu, B., Sirota, M., Guo, S. (2021) A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. eLIFE. 10:
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Vishnolia, K.K., Hoene, C., Tarhbalouti, K., Revenstorff, J., Aherrahrou, Z., Erdmann, J. (2020) Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32. Frontiers in cardiovascular medicine. 7:135
- Fouchécourt, S., Picolo, F., Elis, S., Lécureuil, C., Thélie, A., Govoroun, M., Brégeon, M., Papillier, P., Lareyre, J.J., Monget, P. (2019) An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. BMC Evolutionary Biology. 19:137
- Deng, S., Jia, P.P., Zhang, J.H., Junaid, M., Niu, A., Ma, Y.B., Fu, A., Pei, D.S. (2018) Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of hazardous materials. 357:146-158
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
1 - 10 of 18
Show