Gene
trappc11
- ID
- ZDB-GENE-030131-1723
- Name
- trafficking protein particle complex subunit 11
- Symbol
- trappc11 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including liver development; protein N-linked glycosylation; and protein secretion. Predicted to be located in Golgi apparatus. Used to study autosomal recessive limb-girdle muscular dystrophy type 2S and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157127 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal recessive limb-girdle muscular dystrophy type 2S | Alliance | Muscular dystrophy, limb-girdle, autosomal recessive 18 | 615356 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Trafficking protein particle complex subunit 11 | Trafficking protein particle complex subunit 11, C-terminal |
---|---|---|---|---|
UniProtKB:Q1RLX4 | InterPro | 1132 | ||
UniProtKB:A0A9U5BZX5 | InterPro | 1132 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
trappc11-201
(1)
|
Ensembl | 3,843 nt |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-trappc11 | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-51F19 | ZFIN Curated Data | |
Contained in | BAC | CH211-235C4 | ZFIN Curated Data | |
Encodes | EST | fb78g05 | ||
Encodes | EST | IMAGE:7157127 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:63684 | ZFIN Curated Data | |
Encodes | cDNA | MGC:136723 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_199626 (1) | 3802 nt | ||
Genomic | GenBank:BX890575 (1) | 204730 nt | ||
Polypeptide | UniProtKB:A0A9U5BZX5 (1) | 1132 aa |
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- O'Hare, E.A., Yang, R., Yerges-Armstrong, L., Sreenivasan, U., McFarland, R., Leitch, C.C., Wilson, M.H., Narina, S., Gorden, A., Ryan, K., Shuldiner, A.R., Farber, S.A., Wood, G.C., Still, C.D., Gerhard, G.S., Robishaw, J.D., Sztalryd, C., Zaghloul, N.A. (2017) TM6SF2 rs58542926 impacts lipid processing in liver and small intestine. Hepatology (Baltimore, Md.). 65(5):1526-1542
- Waldron, A.L., Cahan, S.H., Franklyn, C.S., Ebert, A.M. (2017) A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. PLoS One. 12:e0185317
- DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imrie, D., Nayar, S., Baryshnikova, A., Milev, M.P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H.H., Lehrman, M.A., Sacher, M., Sadler, K.C. (2016) trappc11 is required for protein glycosylation in zebrafish and humans. Molecular biology of the cell. 27(8):1220-34
- Fai Tse, W.K., Li, J.W., Kwan Tse, A.C., Chan, T.F., Hin Ho, J.C., Sun Wu, R.S., Chu Wong, C.K., Lai, K.P. (2016) Fatty liver disease induced by perfluorooctane sulfonate: Novel insight from transcriptome analysis. Chemosphere. 159:166-177
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Asaoka, Y., Terai, S., Sakaida, I., and Nishina, H. (2013) The expanding role of fish models in understanding non-alcoholic fatty liver disease. Disease models & mechanisms. 6(4):905-914
- Nguyen, M., Yang, E., Neelkantan, N., Mikhaylova, A., Arnold, R., Poudel, M.K., Stewart, A.M., and Kalueff, A.V. (2013) Developing 'integrative' zebrafish models of behavioral and metabolic disorders. Behavioural brain research. 256C:172-187
- Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508
- Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261
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