Gene
acta2
- ID
- ZDB-GENE-030131-1229
- Name
- actin alpha 2, smooth muscle
- Symbol
- acta2 Nomenclature History
- Previous Names
-
- sma (1)
- wu:fb63d03
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Acts upstream of or within heart contraction. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including cardiovascular system; digestive system; mesoderm; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92120 (15 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-acta2 | N/A | (4) |
| MO2-acta2 | N/A | Wang et al., 2021 |
| MO3-acta2 | N/A | Wang et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Moyamoya disease | Alliance | Moyamoya disease 5 | 614042 |
| thoracic aortic aneurysm | Alliance | Aortic aneurysm, familial thoracic 6 | 611788 |
| Smooth muscle dysfunction syndrome | 613834 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin/actin-like conserved site | Actin, conserved site | Actin family | ATPase, nucleotide binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DHS1 | InterPro | 377 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(acta2:EGFP) |
|
| 1 | (23) | |
| Tg2(acta2:mCherry) |
|
| 1 | (4) | |
| Tg(acta2:GAL4FF,myl7:EGFP) |
|
| 1 | (2) | |
| Tg(acta2:GFP) |
|
| 1 | (4) | |
| Tg(acta2-hsp70l:EGFP) |
|
| 1 | Taminato et al., 2016 | |
| Tg(acta2:mCherry) |
|
| 1 | (14) | |
| TgBAC(acta2:EGFP) |
|
| 1 | Bower et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-369N22 | ZFIN Curated Data | |
| Encodes | EST | fb63d03 | ||
| Encodes | EST | fb64d03 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:92120 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212620 (1) | 1611 nt | ||
| Genomic | GenBank:FO704908 (1) | 108766 nt | ||
| Polypeptide | UniProtKB:Q6DHS1 (1) | 377 aa |
- Chen, S., Xu, J., Xiao, Y., Cai, H., Zhou, J., Cai, W., Wang, Y. (2025) Loss-of-Function of CLMP Is Associated With Congenital Short Bowel Syndrome and Impaired Intestinal Development. Clinical genetics. :
- Wang, C., Zhong, Y., Zhang, Y., Jiang, Y., Wang, C., An, L., Luo, C., Yang, L., He, Z., Yang, Y., Luo, M., Mao, M., Wang, W., Liu, Q., Shi, Y., Ping, Y.F. (2025) Cd248a regulates pericyte development and viability in zebrafish. Communications biology. 8:451451
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Li, C., Cai, R., Shi, W., Zhang, H., Liu, Z., Xie, F., Chen, Y., Hong, Q. (2024) Comparative transcriptome analysis of ovaries and testes reveals sex-biased genes and pathways in zebrafish. Gene. 901:148176
- Sebastian, W.A., Inoue, M., Shimizu, N., Sato, R., Oguri, S., Itonaga, T., Kishimoto, S., Shiraishi, H., Hanada, T., Ihara, K. (2024) Cardiac manifestations of human ACTA2 variants recapitulated in a zebrafish model. Journal of Human Genetics. 69(3-4):133-138
- Zhang, J., Liang, Y., Zeng, W., Gao, X., Wang, D., Mai, C., Lin, Z., Zhao, H., Li, X. (2024) Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model. Animal cells and systems. 28:849284-92
- Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18
- Gafranek, J.T., D'Aniello, E., Ravisankar, P., Thakkar, K., Vagnozzi, R.J., Lim, H.W., Salomonis, N., Waxman, J.S. (2023) Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart. Nature communications. 14:55095509
- Qin, M.C., Li, J.J., Zheng, Y.T., Li, Y.J., Zhang, Y.X., Ou, R.X., He, W.Y., Zhao, J.M., Liu, S.T., Liu, M.H., Lin, H.Y., Gao, L. (2023) Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration. Food & function. 14(23):10347-10361
- Vaz-Rodrigues, R., Mazuecos, L., Villar, M., Contreras, M., Artigas-Jerónimo, S., González-García, A., Gortázar, C., de la Fuente, J. (2023) Multi-omics analysis of zebrafish response to tick saliva reveals biological processes associated with alpha-Gal syndrome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 168:115829115829
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