Gene
map1lc3b
- ID
- ZDB-GENE-030131-1145
- Name
- microtubule-associated protein 1 light chain 3 beta
- Symbol
- map1lc3b Nomenclature History
- Previous Names
-
- Lc3 (1)
- wu:fb60g11
- zgc:56434
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Located in cytosol. Is expressed in several structures, including cardiovascular system; central nervous system; liver; neural tube; and pleuroperitoneal region. Orthologous to several human genes including MAP1LC3B (microtubule associated protein 1 light chain 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56434 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Autophagy protein Atg8 ubiquitin-like | Ubiquitin-like domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q7ZUD8 | InterPro | 122 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
map1lc3b-201
(1)
|
Ensembl | 1,816 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-map1lc3 | polyclonal | Rabbit |
|
Novus Biologicals, LLC
|
16 | ||
| Ab3-map1lc3b | polyclonal | IgG | Rabbit |
|
Abcam plc
|
12 | |
| Ab12-map1lc3b | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
2 | |
| Ab1-map1lc3b | polyclonal | Rabbit |
|
MBL International
|
8 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:mCherry-map1lc3b) |
|
| 1 | Forn-Cuní et al., 2022 | |
| Tg(actb2:mRFP-GFP-map1lc3b) |
| 1 | (3) | ||
| Tg(actc1b:ZsGreen1-map1lc3b,cryaa:tdTomato) |
| 1 | Zebrafish Nomenclature Committee | ||
| Tg(CMV:EGFP-map1lc3b) |
|
| 1 | (53) | |
| Tg(CMV:mCherry-map1lc3b) |
|
| 1 | (4) | |
| Tg(elavl3:EGFP-map1lc3b) |
|
| 1 | (2) | |
| Tg(elavl3:mCherry-EGFP-map1lc3b) |
| 1 | (2) | ||
| Tg(fabp10a:EGFP-map1lc3b) |
|
| 1 | (3) | |
| Tg(gnat2:GFP-map1lc3b) |
|
| 1 | (8) | |
| Tg(gnat2:mCherry-GFP-map1lc3b) |
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-280A23 | ZFIN Curated Data | |
| Encodes | EST | fb60g11 | ||
| Encodes | cDNA | MGC:56434 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174548 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199604 (1) | 1805 nt | ||
| Genomic | GenBank:CU571064 (2) | 159278 nt | ||
| Polypeptide | UniProtKB:Q7ZUD8 (1) | 122 aa |
- Kelu, J.J., Hughes, S.M. (2025) Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia. Proceedings of the National Academy of Sciences of the United States of America. 122:e2422446122e2422446122
- Li, Y., Shi, R., Xia, L., Zhang, X., Zhang, P., Liu, S., Liu, K., Sik, A., Stoika, R., Jin, M. (2025) Identification of Key Active Constituents in Eucommia ulmoides Oliv. Leaves Against Parkinson's Disease and the Alleviative Effects via 4E-BP1 Up-Regulation. International Journal of Molecular Sciences. 26:
- Ye, H., Li, D., Zhang, L., Wang, Y., Wang, C., Jin, M., Lin, H., Li, P., Sun, C., Li, N. (2025) Epicoccin A Ameliorates PD-like Symptoms in Zebrafish: Enhancement of PINK1/Parkin-Dependent Mitophagy and Inhibition of Excessive Oxidative Stress. Marine drugs. 23:
- Chávez, M.N., Arora, P., Meer, M., Marques, I.J., Ernst, A., Morales Castro, R.A., Mercader, N. (2024) Spns1-dependent endocardial lysosomal function drives valve morphogenesis through Notch1-signaling. iScience. 27:111406111406
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Dai, C., Zhang, Y., Gong, Y., Bradley, A., Tang, Z., Sellick, K., Shrestha, S., Spears, E., Covington, B.A., Stanley, J., Jenkins, R., Richardson, T.M., Brantley, R.A., Coate, K., Saunders, D.C., Wright, J.J., Brissova, M., Dean, E.D., Powers, A.C., Chen, W. (2024) Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways. iScience. 27:111447111447
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):
- Kilinç, G., Boland, R., Heemskerk, M.T., Spaink, H.P., Haks, M.C., van der Vaart, M., Ottenhoff, T.H.M., Meijer, A.H., Saris, A. (2024) Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy. Microbiology spectrum. 12(8):e0016724
- Lesport, E., Commeau, L., Genet, M., Baulieu, E.E., Tawk, M., Giustiniani, J. (2024) A decrease in Fkbp52 alters autophagosome maturation and A152T-tau clearance in vivo. Frontiers in Cellular Neuroscience. 18:14252221425222
- Marchese, M., Bernardi, S., Ogi, A., Licitra, R., Silvi, G., Mero, S., Galatolo, D., Gammaldi, N., Doccini, S., Ratto, G.M., Rapposelli, S., Neuhauss, S.C.F., Zang, J., Rocchiccioli, S., Michelucci, E., Ceccherini, E., Santorelli, F.M. (2024) Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model. Neurobiology of disease. 197:106536
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