Gene

agrn

ID
ZDB-GENE-030131-1033
Name
agrin
Symbol
agrn Nomenclature History
Previous Names
  • agrin
  • hm:gc12
  • sb:eu553
  • wu:fb57e07
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and laminin binding activity. Acts upstream of or within anterior/posterior pattern specification; nervous system development; and retina layer formation. Predicted to be located in basement membrane; plasma membrane; and synapse. Predicted to be active in extracellular region. Is expressed in several structures, including immature eye; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 8. Orthologous to human AGRN (agrin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la022570TgTransgenic insertionUnknownUnknownDNA
la022571TgTransgenic insertionUnknownUnknownDNA
p168Allele with one delinsDonor Splice Site of Exon 31UnknownCRISPR
sa381Allele with one point mutationUnknownSplice SiteENU
sa11435Allele with one point mutationUnknownSplice SiteENU
sa12413Allele with one point mutationUnknownPremature StopENU
sa15437Allele with one point mutationUnknownSplice SiteENU
sa25196Allele with one point mutationUnknownPremature StopENU
sa29921Allele with one point mutationUnknownPremature StopENU
sa43979Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-agrn (3)
MO1-agrnN/A (2)
MO2-agrnN/A (6)
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Human Disease
Associated With agrn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myasthenic syndrome 8 Alliance Myasthenic syndrome, congenital, 8, with pre- and postsynaptic defects 615120
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Associated With agrn Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000082 SEA domain
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR002049 Laminin-type EGF domain
1 - 5 of 14 Show all
Domain Details Per Protein
Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding domain EGF-like domain Factor I / membrane attack complex Follistatin-like, N-terminal Kazal domain Kazal domain superfamily Laminin G domain Laminin-type EGF domain NtA (N-terminal agrin) domain Protease Inhibitors and Growth Factor Antagonists SEA domain SEA domain superfamily Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:B3GQ72 InterPro 2028
UniProtKB:A0A0R4IJ40 InterPro 1926
UniProtKB:A0A8M9PT59 InterPro 1947
UniProtKB:A0A8M9PT52 InterPro 2052
UniProtKB:A0A8M9PWK3 InterPro 1949
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 23
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA agrn-201 (1) Ensembl 6,239 nt
mRNA agrn-202 (1) Ensembl 8,434 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
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Sequences
Orthology
Comparative Orthology
Alliance
Species Symbol Chromosome Accession # Evidence
HumanAGRN1
Conserved genome location (synteny) (2)
Amino acid sequence comparison (1)
MouseAgrn4
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
1 - 10 of 27
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