Gene

epb41b

ID
ZDB-GENE-030130-1
Name
erythrocyte membrane protein band 4.1b
Symbol
epb41b Nomenclature History
Previous Names
  • epb41
  • P4.1R (1)
  • cha (1)
  • chablis (1)
  • merlot
  • mot
  • protein 4.1R (1)
  • wu:fb70c02 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Enables calmodulin binding activity. Acts upstream of or within embryonic hemopoiesis and erythrocyte differentiation. Located in plasma membrane. Is expressed in blood; liver; ovary; and pericardial region. Human ortholog(s) of this gene implicated in hereditary elliptocytosis. Orthologous to human EPB41 (erythrocyte membrane protein band 4.1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
epb41b_unspecifiedUnspecified AlleleUnknownUnknownnot specified
sa15697Allele with one point mutationUnknownPremature StopENU
sa36150Allele with one point mutationUnknownPremature StopENU
sa36151Allele with one point mutationUnknownPremature StopENU
sa42730Allele with one point mutationUnknownPremature StopENU
sa45577Allele with one point mutationUnknownPremature StopENU
tm303cAllele with one point mutationUnknownPremature StopENU
tu275Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With epb41b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary elliptocytosis Alliance Elliptocytosis-1 611804
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Associated With epb41b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019747 FERM conserved site
Domain IPR000299 FERM domain
Domain IPR007477 SAB domain
Domain IPR014847 FERM adjacent
Domain IPR018979 FERM, N-terminal
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Domain Details Per Protein
Protein Additional Resources Length Band 4.1 domain Ezrin/radixin/moesin-like FERM/acyl-CoA-binding protein superfamily FERM adjacent FERM central domain FERM conserved site FERM, C-terminal PH-like domain FERM domain FERM, N-terminal FERM superfamily, second domain PH-like domain superfamily SAB domain Ubiquitin-like domain superfamily
UniProtKB:Q8JG61 InterPro 1534
UniProtKB:A0AB32T9B4 InterPro 1370
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 16
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA epb41b-201 (1) Ensembl 5,160 nt
ncRNA epb41b-002 (1) Ensembl 500 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-epb41 polyclonal Rabbit
  • IHC
  • WB
2
Ab2-epb41 polyclonal Rabbit
  • IHC
  • WB
2
1 - 2 of 2
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-168I6ZFIN Curated Data
Contained inBACDKEY-108F8ZFIN Curated Data
EncodesESTfb70c02ZFIN Curated Data
EncodescDNAMGC:193936ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanEPB411
Amino acid sequence comparison (2)
MouseEpb414
Amino acid sequence comparison (2)
Citations
1 - 10 of 20
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