Gene
mbpa
- ID
- ZDB-GENE-030128-2
- Name
- myelin basic protein a
- Symbol
- mbpa Nomenclature History
- Previous Names
-
- mbp
- cb274 (1)
- fj33b11
- wu:fj33b11
- wu:fq15b02
- zgc:136630
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Located in myelin sheath and plasma membrane. Is expressed in several structures, including EVL; male organism; nervous system; otic vesicle; and periderm. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MBP (myelin basic protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 198 figures from 116 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb274 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-mbpa | (2) | |
CRISPR2-mbpa | (2) | |
CRISPR3-mbpa | (2) | |
CRISPR4-mbpa | (2) | |
MO1-mbpa | N/A | Boczonadi et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR000548 | Myelin basic protein |
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Domain Details Per Protein
Protein | Additional Resources | Length | Myelin basic protein |
---|---|---|---|
UniProtKB:F8W3W8 | InterPro | 95 | |
UniProtKB:I3ITP3 | InterPro | 137 | |
UniProtKB:A0A8M9P2C7 | InterPro | 130 | |
UniProtKB:F8W2M5 | InterPro | 91 | |
UniProtKB:Q5I2C7 | InterPro | 88 |
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Interactions and Pathways
No data available
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(1mbp:EGFP) |
|
| 1 | (17) | |
Tg2(mbpa:Dendra2) |
|
| 1 | (3) | |
Tg2(mbpa:Dendra2-UTR) |
|
| 1 | Torvund-Jensen et al., 2018 | |
Tg2(mbpa:EGFP-CAAX) |
|
| 1 | (2) | |
Tg2(mbpa:mCherry-CAAX) |
|
| 1 | (2) | |
Tg(mbpa:Citrine) |
|
| 1 | Ashikawa et al., 2016 | |
Tg(mbpa:Dendra2) |
|
| 1 | Torvund-Jensen et al., 2018 | |
Tg(mbpa:Dendra2-CAAX) |
|
| 1 | (3) | |
Tg(mbpa:Dendra2-UTR) |
|
| 1 | Torvund-Jensen et al., 2018 | |
Tg(mbpa:EGFP-CAAX) |
|
| 1 | Strachan et al., 2017 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-207C1 | ZFIN Curated Data | |
Encodes | EST | cb274 | Thisse et al., 2001 | |
Encodes | EST | fj33a07 | ||
Encodes | EST | fj33b11 | ZFIN Curated Data | |
Encodes | EST | fq15b02 | Rauch et al., 2003 | |
Encodes | cDNA | MGC:136630 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001020483 (1) | 1733 nt | ||
Genomic | GenBank:CU856623 (2) | 62435 nt | ||
Polypeptide | UniProtKB:I3ITP3 (1) | 137 aa |
- Doan, R.A., Monk, K.R. (2025) Dock1 functions in Schwann cells to regulate development, maintenance, and repair. The Journal of cell biology. 224:
- Eghan, K., Lee, S., Yoo, D., Kim, W.K. (2025) 2-Ethylhexanol induces autism-like neurobehavior and neurodevelopmental disorders in zebrafish. Journal of hazardous materials. 488:137469137469
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Bromley-Coolidge, S., Iruegas, D., Appel, B. (2024) Cspg4 sculpts oligodendrocyte precursor cell morphology. Differentiation; research in biological diversity. 140:100819100819
- Iyer, H., Talbot, W.S. (2024) Chloride transporter ClC-7 is essential for phagocytic clearance by microglia. Journal of Cell Science. 137(4):
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Saraswathy, V.M., Zhou, L., Mokalled, M.H. (2024) Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair. Nature communications. 15:68086808
- Accogli, A., Lin, S.J., Severino, M., Kim, S.H., Huang, K., Rocca, C., Landsverk, M., Zaki, M., Al-Maawali, A., Srinivasan, V.M., Al-Thihli, K., Schaefer, G.B., Davis, M., Tonduti, D., Doneda, C., Marten, L.M., Mühlhausen, C., Gomez, M., Lamantea, E., Mena, R., Nizon, M., Procaccio, V., Begtrup, A., Telegrafi, A., Cui, H., Schulz, H.L., Mohr, J., Biskup, S., Loos, M.A., Aráoz, H.V., Salpietro, V., Keppen, L.D., Chitre, M., Petree, C., Raymond, L., Vogt, J., Swayer, L.B., Basinger, A.A., Pedersen, S.V., Pearson, T.S., Grange, D.K., Lingapp, L., McDunnah, P., Horvath, R., Cogne, B., Isidor, B., Hahn, A., Gripp, K., Jafarnejad, S.M., Ostergaard, E., Prada, C.E., Ghezzi, D., Gowda, V.K., Taylor, R.W., Sonenberg, N., Houlden, H., Sissler, M., Varshney, G.K., Maroofian, R. (2023) Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 25(11):100938
- Bouchard, E.L., Meireles, A.M., Talbot, W.S. (2023) Oligodendrocyte development and myelin sheath formation are regulated by the antagonistic interaction between the Rag-Ragulator complex and TFEB. Glia. 72(2):289-299
- Kaiyrzhanov, R., Rad, A., Lin, S.J., Bertoli-Avella, A., Kallemeijn, W.W., Godwin, A., Zaki, M.S., Huang, K., Lau, T., Petree, C., Efthymiou, S., Ghayoor Karimiani, E., Hempel, M., Normand, E.A., Rudnik-Schöneborn, S., Schatz, U.A., Baggelaar, M.P., Ilyas, M., Sultan, T., Alvi, J.R., Ganieva, M., Fowler, B., Aanicai, R., Akay Tayfun, G., Al Saman, A., Alswaid, A., Amiri, N., Asilova, N., Shotelersuk, V., Yeetong, P., Azam, M., Babaei, M., Bahrami Monajemi, G., Mohammadi, P., Samie, S., Banu, S.H., Basto, J.P., Kortüm, F., Bauer, M., Bauer, P., Beetz, C., Garshasbi, M., Hameed Issa, A., Eyaid, W., Ahmed, H., Hashemi, N., Hassanpour, K., Herman, I., Ibrohimov, S., Abdul-Majeed, B.A., Imdad, M., Isrofilov, M., Kaiyal, Q., Khan, S., Kirmse, B., Koster, J., Lourenço, C.M., Mitani, T., Moldovan, O., Murphy, D., Najafi, M., Pehlivan, D., Rocha, M.E., Salpietro, V., Schmidts, M., Shalata, A., Mahroum, M., Talbeya, J.K., Taylor, R.W., Vazquez, D., Vetro, A., Waterham, H.R., Zaman, M., Schrader, T.A., Chung, W.K., Guerrini, R., Lupski, J.R., Gleeson, J., Suri, M., Jamshidi, Y., Bhatia, K.P., Vona, B., Schrader, M., Severino, M., Guille, M., Tate, E.W., Varshney, G.K., Houlden, H., Maroofian, R. (2023) Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders. Brain : a journal of neurology. 147(4):1436-1456
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