Gene
ruvbl2
- ID
- ZDB-GENE-030109-1
- Name
- RuvB-like AAA ATPase 2
- Symbol
- ruvbl2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Enables ATP hydrolysis activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Predicted to be located in dynein axonemal particle and nucleus. Predicted to be part of MLL1 complex; R2TP complex; and chromatin. Is expressed in central nervous system; neural tube; posterior lateral line; and pronephric duct. Orthologous to human RUVBL2 (RuvB like AAA ATPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63723 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ruvbl2 | Sharpe et al., 2022 | |
| CRISPR2-ruvbl2 | Sharpe et al., 2022 | |
| CRISPR3-ruvbl2 | LaCoursiere et al., 2024 | |
| CRISPR4-ruvbl2 | LaCoursiere et al., 2024 | |
| MO1-ruvbl2 | N/A | Zhao et al., 2013 |
| MO2-ruvbl2 | N/A | Huang et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | P-loop containing nucleoside triphosphate hydrolase | RuvBL1/2, DNA/RNA binding domain | RuvB-like | RuvB-like, AAA-lid domain | TIP49, P-loop domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:P83571 | InterPro | 463 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ruvbl2-201
(1)
|
Ensembl | 1,712 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ruvbl2 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
3 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:3xHA-ruvbl2,eef1a1l1:EGFP) |
| 1 | Sharpe et al., 2022 | ||
| Tg(myl7:NLS-EGFP-2A-ruvbl2) |
| 1 | Sharpe et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-7B17 | ZFIN Curated Data | |
| Encodes | EST | fi25f01 | ||
| Encodes | cDNA | MGC:63723 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_174860 (1) | 1735 nt | ||
| Genomic | GenBank:BX005059 (1) | 194603 nt | ||
| Polypeptide | UniProtKB:P83571 (1) | 463 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Sharpe, M., González-Rosa, J.M., Wranitz, F., Jeffrey, S., Copenhaver, K., Burns, C.G., Burns, C.E. (2022) Ruvbl2 Suppresses Cardiomyocyte Proliferation During Zebrafish Heart Development and Regeneration. Frontiers in cell and developmental biology. 10:800594
- Sun, H., Chen, M., Wang, Z., Zhao, G., Liu, J.X. (2019) Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental pollution (Barking, Essex : 1987). 256:113364
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Langevin, C., Aleksejeva, E., Houel, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J.P., Boudinot, P. (2017) FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Frontiers in immunology. 8:617
- Li, Y., Zhao, L., Yuan, S., Zhang, J., Sun, Z. (2017) Axonemal dynein assembly requires the R2TP complex component Pontin. Development (Cambridge, England). 144(24):4684-4693
- Frøyset, A.K., Khan, E.A., Fladmark, K.E. (2016) Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Scientific Reports. 6:29631
- Leontovich, A.A., Intine, R.V., Sarras, M.P. (2016) Epigenetic Studies Point to DNA Replication/Repair Genes as a Basis for the Heritable Nature of Long Term Complications in Diabetes. Journal of Diabetes Research. 2016:2860780
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Zhao, L., Yuan, S., Cao, Y., Kallakuri, S., Li, Y., Kishimoto, N., Dibella, L., and Sun, Z. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proceedings of the National Academy of Sciences of the United States of America. 110(31):12697-702
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