Gene

irx7

ID
ZDB-GENE-020103-1
Name
iroquois homeobox 7
Symbol
irx7 Nomenclature History
Previous Names
  • iro7
  • cb263 (1)
  • zgc:109841
  • ziro7 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal joint development; nervous system development; and retina morphogenesis in camera-type eye. Predicted to be active in nucleus. Is expressed in several structures, including head; interhyal-hyosymplectic joint; nervous system; neural keel; and neural plate.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
el538Allele with one delinsUnknownUnknownTALEN
el540Allele with one deletionUnknownUnknownTALEN
nksagp011GtTransgenic insertionExon 2UnknownDNA
sa24393Allele with one point mutationUnknownPremature StopENU
sa32464Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-irx7N/A (3)
MO2-irx7N/A (3)
MO3-irx7N/A (3)
TALEN1-irx7 (3)
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Human Disease
Associated With irx7 Human Ortholog
No data available
Associated With irx7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR003893 Iroquois-class homeodomain protein
Domain IPR008422 KN homeodomain
Homologous_superfamily IPR009057 Homedomain-like superfamily
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Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeodomain Iroquois-class homeodomain protein KN homeodomain
UniProtKB:Q90YX8 InterPro 314
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 23
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA irx7-201 (1) Ensembl 1,187 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-irx7 polyclonal Rabbit
  • WB
1
Ab2-irx7 polyclonal Rabbit
  • WB
1
Ab3-irx7 polyclonal Rabbit
1
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg(UAS:irx7-2A-EGFP,cryaa:Cerulean)
  • Danio rerio
1Askary et al., 2015
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-231H20ZFIN Curated Data
EncodesESTcb263 (2)
EncodescDNAMGC:109841ZFIN Curated Data
EncodescDNAMGC:191512ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
No data available
Citations
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