Gene
nanos3
- ID
- ZDB-GENE-011221-1
- Name
- nanos homolog 3
- Symbol
- nanos3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables identical protein binding activity and single-stranded RNA binding activity. Involved in germ cell development; germ cell migration; and negative regulation of protein phosphorylation. Acts upstream of or within female germ-line stem cell population maintenance and oocyte growth. Located in P granule. Is expressed in blastodisc; forebrain; germ line cell; reproductive system; and unfertilized egg. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 36 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb725 (21 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh49 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nanos3 | Sun et al., 2019 | |
| CRISPR2-nanos3 | Sun et al., 2019 | |
| MO1-nanos3 | N/A | Köprunner et al., 2001 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nanos domain superfamily | Nanos/Xcat2 | Zinc finger, nanos-type |
|---|---|---|---|---|---|
| UniProtKB:Q90WW1 | InterPro PDB | 159 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nanos3-201
(1)
|
Ensembl | 1,127 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB1-nanos3 | polyclonal | Mouse |
|
1 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(kop:EGFP-FTASE-UTR-nanos3) |
| 2 | (35) | ||
| Tg(hsp70l:cxcl12a-UTR-nanos3,EGFP-UTR-nanos3) |
| 1 | (2) | ||
| Tg(kop:Cre-UTR-nanos3,CMV:EGFP) |
| 1 | (5) | ||
| Tg(kop:DsRed-UTR-nanos3) |
|
| 1 | (3) | |
| Tg(kop:DsRedx-UTR-nanos3) |
|
| 1 | (3) | |
| Tg(kop:EGFP-actb2-UTR-nanos3) |
| 1 | (3) | ||
| Tg(kop:EGFP-FTASE-nanos3,cryaa:DsRed) |
| 1 | (2) | ||
| Tg(kop:EGFP-LIFEACT-UTR-nanos3) |
| 1 | (10) | ||
| Tg(kop:gra-DsRedx-UTR-nanos3) |
| 1 | (7) | ||
| Tg(kop:LIFEACT-mCherry-UTR-nanos3,cryaa:DsRed) |
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-286B5 | ZFIN Curated Data | |
| Encodes | EST | cb725 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:114022 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131878 (1) | 1141 nt | ||
| Genomic | GenBank:BX284640 (1) | 158537 nt | ||
| Polypeptide | UniProtKB:Q90WW1 (1) | 159 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ruan, Y., Li, X., Zhai, G., Lou, Q., Jin, X., He, J., Yin, Z. (2024) Estrogen Signaling Inhibits the Expression of anti-Müllerian hormone (amh) and gonadal-soma-derived factor (gsdf) during the Critical Time of Sexual Fate Determination in Zebrafish. International Journal of Molecular Sciences. 25(3):
- Li, W., Liu, W., Mo, C., Yi, M., Gui, J. (2023) Two Novel lncRNAs Regulate Primordial Germ Cell Development in Zebrafish. Cells. 12(4):
- Liao, X., Tao, B., Zhang, X., Chen, L., Chen, J., Song, Y., Hu, W. (2023) Loss of gdnfa disrupts spermiogenesis and male courtship behavior in zebrafish. Molecular and Cellular Endocrinology. 576:112010
- Wang, F., Feng, Y.Y., Wang, X.G., Ou, M., Zhang, X.C., Zhao, J., Chen, K.C., Li, K.B. (2023) Production of all-male non-transgenic zebrafish by conditional primordial germ cell ablation. Fish physiology and biochemistry. 49(6):1215-1227
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Westerich, K.J., Reinecke, S., Emich, J., Wyrwoll, M.J., Stallmeyer, B., Meyer, M., Oud, M.S., Fietz, D., Pilatz, A., Kliesch, S., Reichman-Fried, M., Tarbashevich, K., Limon, T., Stehling, M., Friedrich, C., Tüttelmann, F., Raz, E. (2023) Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Human reproduction (Oxford, England). 38(4):655-670
- Chang, N.C., Rovira, Q., Wells, J.N., Feschotte, C., Vaquerizas, J.M. (2022) Zebrafish transposable elements show extensive diversification in age, genomic distribution, and developmental expression. Genome research. 32(7):1408-1423
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
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