Gene
per1a
- ID
- ZDB-GENE-011220-1
- Name
- period circadian clock 1a
- Symbol
- per1a Nomenclature History
- Previous Names
-
- per1
- si:ch211-237l4.4
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable transcription cis-regulatory region binding activity and transcription corepressor binding activity. Acts upstream of or within photoperiodism and response to hydrogen peroxide. Predicted to be active in cytoplasm and nucleus. Is expressed in brain. Orthologous to human PER1 (period circadian regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb916 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb917 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa14433 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16532 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41652 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PAS domain | PAS domain superfamily | PAS fold-3 | Period circadian-like, C-terminal | Period circadian protein homolog 1-3, PAS-A domain | Period circadian regulator |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PTL7 | InterPro | 1330 | ||||||
| UniProtKB:A0A8M2BJY2 | InterPro | 1386 | ||||||
| UniProtKB:A0A8M2BJX1 | InterPro | 1386 | ||||||
| UniProtKB:Q7SZZ4 | InterPro | 1229 | ||||||
| UniProtKB:A0A0R4ICG0 | InterPro | 1387 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-237L4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195100 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030183 (1) | 3690 nt | ||
| Genomic | GenBank:AL807389 (1) | 143672 nt | ||
| Polypeptide | UniProtKB:A0A0R4ICG0 (1) | 1387 aa |
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Godino-Gimeno, A., Leal, E., Chivite, M., Tormos, E., Rotllant, J., Vallone, D., Foulkes, N.S., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish. Journal of pineal research. 76:e12939e12939
- Liu, T., He, W., Zhong, Z., Lu, C., Wu, L., Wang, Z., Smith, W.K., Shi, Q., Long, Q., Wang, H. (2024) The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates. National science review. 12:nwae456nwae456
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Wu, L., Zhao, M., Chen, X., Wang, H. (2024) A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish. Communications biology. 7:16711671
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Crnko, S., Printezi, M.I., Zwetsloot, P.M., Leiteris, L., Lumley, A.I., Zhang, L., Ernens, I., Jansen, T.P.J., Homsma, L., Feyen, D., van Faassen, M., du Pré, B.C., Gaillard, C.A.J.M., Kemperman, H., Oerlemans, M.I.F.J., Doevendans, P.A.F.M., May, A.M., Zuithoff, N.P.A., Sluijter, J.P.G., Devaux, Y., van Laake, L.W. (2023) The circadian clock remains intact, but with dampened hormonal output in heart failure. EBioMedicine. 91:104556104556
- Luckner, B., Essfeld, F., Ayobahan, S.U., Richling, E., Eilebrecht, E., Eilebrecht, S. (2023) Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression. Ecotoxicology and environmental safety. 266:115570115570
- Dekens, M.P.S., Fontinha, B.M., Gallach, M., Pflügler, S., Tessmar-Raible, K. (2022) Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish. EMBO reports. 23(5):e51528
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