Gene
cyp1a
- ID
- ZDB-GENE-011219-1
- Name
- cytochrome P450, family 1, subfamily A
- Symbol
- cyp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen and steroid hydroxylase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including digestive system; pectoral fin bud; pericardial region; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including CYP1A2 (cytochrome P450 family 1 subfamily A member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 124 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7163229 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| biz1 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la027978Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17179 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyp1a | (2) | |
| CRISPR2-cyp1a | (2) | |
| CRISPR3-cyp1a | (2) | |
| CRISPR4-cyp1a | (2) | |
| CRISPR5-cyp1a | (2) | |
| MO1-cyp1a | N/A | (13) |
| MO2-cyp1a | N/A | Antkiewicz et al., 2006 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP1 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UW07 | InterPro | 519 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp1a | monoclonal | IgG3 , k | Mouse |
|
Cayman Chemical Company
Biosense Laboratories |
10 | |
| Ab3-cyp1a | monoclonal | IgG | Mouse |
|
Absolute Biotech
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(cyp1a:mCherry) |
|
| 1 | (2) | |
| TgBAC(cyp1a:NLS-EGFP) |
|
| 1 | (8) | |
| Tg(cyp1a-6xDIRE:EGFP) |
|
| 1 | Shen et al., 2018 | |
| Tg(cyp1a-12xDIRE:EGFP) |
|
| 1 | (3) | |
| Tg(cyp1a:ECFP) |
|
| 1 | Chen et al., 2022 | |
| Tg(cyp1a:mCherry) |
|
| 3 | Xie et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-392K22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7163229 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:109747 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193050 | ZFIN Curated Data | |
| Has Artifact | EST | fb63b04 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131879 (1) | 2608 nt | ||
| Genomic | GenBank:CU462829 (2) | 31938 nt | ||
| Polypeptide | UniProtKB:Q8UW07 (1) | 519 aa |
- Erradhouani, C., Piccini, B., Maillot-Marechal, E., Aït-Aïssa, S., Balaguer, P., Coumoul, X., Brion, F. (2025) New insights into the regulation of cyp3a65 expression in transgenic tg(cyp3a65:GFP) zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 279:107250107250
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Veroni, C., Olla, S., Brignone, M.S., Siguri, C., Formato, A., Marra, M., Manzoli, R., Macario, M.C., Ambrosini, E., Moro, E., Agresti, C. (2024) The Antioxidant Drug Edaravone Binds to the Aryl Hydrocarbon Receptor (AHR) and Promotes the Downstream Signaling Pathway Activation. Biomolecules. 14(4):
- Dasgupta, S., La Du, J.K., Garcia, G.R., Li, S., Tomono-Duval, K., Rericha, Y., Huang, L., Tanguay, R.L. (2023) A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 194(2):153-166
- Feng, J., Chen, X., Wang, S., Zhang, J., Wang, Q., Guo, S., Shen, Q. (2023) Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish. Food & function. 14(8):3641-3658
- Rude, C.I., Tidwell, L.G., Tilton, S.C., Waters, K.M., Anderson, K.A., Tanguay, R.L. (2023) Coupling Environmental Whole Mixture Toxicity Screening with Unbiased RNA-Seq Reveals Site-Specific Biological Responses in Zebrafish. Toxics. 11(3):
- Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589
- Anderson, A.L., Dubanksy, B.D., Wilson, L.B., Tanguay, R.L., Rice, C.D. (2022) Development and Applications of a Zebrafish (Danio rerio) CYP1A-Targeted Monoclonal Antibody (CRC4) with Reactivity across Vertebrate Taxa: Evidence for a Conserved CYP1A Epitope. Toxics. 10(7):
- Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
- Chen, J., Zhang, M., Zou, H., Aniagu, S., Jiang, Y., Chen, T. (2022) Synergistic protective effects of folic acid and resveratrol against fine particulate matter-induced heart malformations in zebrafish embryos. Ecotoxicology and environmental safety. 241:113825
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