Gene
vcana
- ID
- ZDB-GENE-011023-1
- Name
- versican a
- Symbol
- vcana Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Acts upstream of or within endocardial cushion morphogenesis; pronephric glomerulus morphogenesis; and regulation of glomerular filtration. Predicted to be located in several cellular components, including extracellular region; interphotoreceptor matrix; and photoreceptor outer segment. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including anterior neural keel; mesoderm; otic vesicle; pericardial region; and semicircular canal. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human VCAN (versican).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 65 figures from 49 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb63 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| pd3001 | Allele with one deletion | Exon 4 | Unknown | CRISPR | |
| sa1460 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa2210 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa15511 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15805 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17232 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17331 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17829 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20520 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33699 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vcana | Capon et al., 2017 | |
| CRISPR2-vcana | Mori et al., 2024 | |
| CRISPR3-vcana | Mori et al., 2024 | |
| CRISPR4-vcana | Mori et al., 2024 | |
| MO1-vcana | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Wagner syndrome 1 | 143200 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aggrecan/versican, C-type lectin-like domain | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Hyaluronan-binding Proteoglycan | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Link domain | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8Q3K1 | InterPro | 635 | ||||||||||||||||||
| UniProtKB:A0A8M9PX21 | InterPro | 8936 | ||||||||||||||||||
| UniProtKB:A0AB32TV09 | InterPro | 663 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-84I7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-251O17 | ZFIN Curated Data | |
| Encodes | EST | cb63 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001326557 (1) | 2024 nt | ||
| Genomic | GenBank:BX465199 (1) | 218103 nt | ||
| Polypeptide | UniProtKB:A0A8M9PX21 (1) | 8936 aa |
- Mori, Y., Smith, S., Wang, J., Eliora, N., Heikes, K.L., Munjal, A. (2024) Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Development (Cambridge, England). 152(1):
- Auman, H.J., Fernandes, I.H., Berríos-Otero, C.A., Colombo, S., Yelon, D. (2023) Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):157-172
- Mackowetzky, K., Dicipulo, R., Fox, S.C., Philibert, D.A., Todesco, H., Doshi, J.D., Kawakami, K., Tierney, K., Waskiewicz, A.J. (2022) Retinoic Acid Signaling Regulates Late Stages of Semicircular Canal Morphogenesis and Otolith Maintenance in the Zebrafish Inner Ear. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(11):1798-1815
- Casey, M.A., Hill, J.T., Hoshijima, K., Bryan, C.D., Gribble, S.L., Brown, J.T., Chien, C.B., Yost, H.J., Kwan, K.M. (2021) Shutdown corner, a large deletion mutant isolated from a haploid mutagenesis screen in zebrafish. G3 (Bethesda). 12(3):
- Mahony, C.B., Cacialli, P., Pasche, C., Monteiro, R., Savvides, S.N., Bertrand, J.Y. (2021) Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis. Blood advances. 5(23):4935-4948
- Peng, X., Feng, G., Zhang, Y., Sun, Y. (2021) PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction. International Journal of Molecular Sciences. 22(21):
- Tessadori, F., Tsingos, E., Colizzi, E.S., Kruse, F., van den Brink, S.C., van den Boogaard, M., Christoffels, V.M., Merks, R.M., Bakkers, J. (2021) Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process. eLIFE. 10:
- Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
- Gou, D., Zhou, J., Song, Q., Wang, Z., Bai, X., Zhang, Y., Zuo, M., Wang, F., Chen, A., Yousaf, M., Yang, Z., Peng, H., Li, K., Xie, W., Tang, J., Yao, Y., Han, M., Ke, T., Chen, Q., Xu, C., Wang, Q. (2020) Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signaling in zebrafish. Acta physiologica (Oxford, England). 231(3):e13567
- Holowiecki, A., Linstrum, K., Ravisankar, P., Chetal, K., Salomonis, N., Waxman, J.S. (2020) Pbx4 limits heart size and fosters arch artery formation through partitioning second heart field progenitors and restricting proliferation. Development (Cambridge, England). 147(5):
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