PUBLICATION

UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish

Authors
Walsh, E.C. and Stainier, D.Y.
ID
ZDB-PUB-010912-9
Date
2001
Source
Science (New York, N.Y.)   293(5535): 1670-1673 (Journal)
Registered Authors
Stainier, Didier, Walsh, Emily
Keywords
endocardial cushion formation, TGF-beta receptor, cell-transformation, neuregulin receptor, heart, gene, biosynthesis, Drosophila, morphogenesis, proteoglycans
MeSH Terms
  • Heart/embryology*
  • Animals
  • Female
  • Myocardium/cytology
  • Myocardium/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Glycosaminoglycans/metabolism
  • Signal Transduction
  • Mutation
  • Bone Morphogenetic Proteins/genetics
  • Male
  • Phenotype
  • Uridine Diphosphate Glucose Dehydrogenase/genetics*
  • Uridine Diphosphate Glucose Dehydrogenase/metabolism*
  • Physical Chromosome Mapping
  • Heart Valves/cytology
  • Heart Valves/embryology*
  • Heart Valves/enzymology
  • Heart Valves/metabolism
  • Endocardium/embryology
  • Endocardium/metabolism
  • Molecular Sequence Data
  • Body Patterning
  • Amino Acid Sequence
  • Morphogenesis
  • Antisense Elements (Genetics)
  • Gene Expression
(all 28)
PubMed
11533493 Full text @ Science
Abstract
Cardiac valve formation is a complex process that involves cell signaling events between the myocardial and endocardial layers of the heart across an elaborate extracellular matrix. These signals lead to marked morphogenetic movements and transdifferentiation of the endocardial cells at chamber boundaries. Here we identify the genetic defect in zebrafish jekyll mutants, which are deficient in the initiation of heart valve formation. The jekyll mutation disrupts a homolog of Drosophila Sugarless, a uridine 5'-diphosphate (UDP)-glucose dehydrogenase required for heparan sulfate, chondroitin sulfate, and hyaluronic acid production. The atrioventricular border cells do not differentiate from their neighbors in jekyll mutants, suggesting that Jekyll is required in a cell signaling event that establishes a boundary between the atrium and ventricle.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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Citation
Walsh, E.C. and Stainier, D.Y. (2001) UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science (New York, N.Y.). 293(5535):1670-1673.