Gene

ncam1b

ID

ZDB-GENE-010822-2

Name

neural cell adhesion molecule 1b

Symbol

ncam1b Nomenclature History

Previous Names

ncam3
zPCAM (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Acts upstream of or within axon guidance. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in nervous system; otic vesicle; posterior neural keel; spinal cord neural rod; and spinal cord neural tube. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cssl:d097 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Langhauser et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ncam1b Human Ortholog

No data available

Associated With ncam1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR009138	Neural cell adhesion
Family	IPR050958	Cell Adhesion and Cytoskeletal Organization
Family	IPR051170	Neural and epithelial cell adhesion domain-containing protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3ASL0	InterPro	866
UniProtKB:A0A8M2B3P6	InterPro	1055
UniProtKB:A0A8M2B488	InterPro	1047
UniProtKB:A0A8M2B466	InterPro	1039
UniProtKB:A0A8M3AH81	InterPro	1044
UniProtKB:A0A8M6Z9Y9	InterPro	1042
UniProtKB:A0A8M2B3H7	InterPro	1038
UniProtKB:A0A8M3APN8	InterPro	1045
UniProtKB:A0A8M3ASK5	InterPro	1049
UniProtKB:A0A8M2B493	InterPro	1020
UniProtKB:A0A8M2B3I6	InterPro	1037
UniProtKB:A0A8M3B0V3	InterPro	1054
UniProtKB:A0A8M2B3Q1	InterPro	1030
UniProtKB:A0A8M3B0W0	InterPro	1043
UniProtKB:Q90YM2	InterPro	1031
UniProtKB:A0A8M3AID4	InterPro	1050
UniProtKB:A0A8M3APP3	InterPro	753
UniProtKB:A0A8M3AH87	InterPro	1021
UniProtKB:A0A8M3AID9	InterPro	917
UniProtKB:A0AB32T118	InterPro	1041
UniProtKB:A0AB32T120	InterPro	1044
UniProtKB:A0AB32T2C3	InterPro	865
UniProtKB:A0AB32T307	InterPro	849
UniProtKB:A0AB32T3D3	InterPro	831
UniProtKB:A0AB32T3S8	InterPro	1036
UniProtKB:A0AB32T6Q2	InterPro	916
UniProtKB:A0AB32T7Z8	InterPro	1046
UniProtKB:A0AB32T8E8	InterPro	752

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ncam1b-201 (1) Ensembl	Ensembl	3,738 nt	Select Tool ZFIN BLAST
mRNA	ncam1b-202 (1) Ensembl	Ensembl	961 nt	Select Tool ZFIN BLAST
mRNA	ncam1b-203 (1) Ensembl	Ensembl	3,738 nt	Select Tool ZFIN BLAST
mRNA	ncam1b-204 (1) Ensembl	Ensembl	812 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-ncam1b	polyclonal	ncam1b		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations