Gene
ncam1b
- ID
- ZDB-GENE-010822-2
- Name
- neural cell adhesion molecule 1b
- Symbol
- ncam1b Nomenclature History
- Previous Names
-
- ncam3
- zPCAM (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within axon guidance. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Is expressed in nervous system; otic vesicle; posterior neural keel; spinal cord neural rod; and spinal cord neural tube. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; drug dependence; middle cerebral artery infarction; and nicotine dependence. Orthologous to human NCAM1 (neural cell adhesion molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d097 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Langhauser et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ka901 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| ka902 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la019186Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019189Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35854 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35855 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42522 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 7 of 7
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cell Adhesion and Cytoskeletal Organization | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neural and epithelial cell adhesion domain-containing protein | Neural cell adhesion |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASL0 | InterPro | 866 | |||||||||||
| UniProtKB:A0A8M2B3P6 | InterPro | 1055 | |||||||||||
| UniProtKB:A0A8M2B488 | InterPro | 1047 | |||||||||||
| UniProtKB:A0A8M2B466 | InterPro | 1039 | |||||||||||
| UniProtKB:A0A8M3AH81 | InterPro | 1044 |
1 - 5 of 28 Show all
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ncam1b-201
(1)
|
Ensembl | 3,738 nt | ||
| mRNA |
ncam1b-202
(1)
|
Ensembl | 961 nt | ||
| mRNA |
ncam1b-203
(1)
|
Ensembl | 3,738 nt | ||
| mRNA |
ncam1b-204
(1)
|
Ensembl | 812 nt |
1 - 4 of 4
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ncam1b | polyclonal | Rabbit |
|
2 |
1 - 1 of 1
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-78D3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-85H21 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d097 | Bushell et al., 2007 | |
| Encodes | cDNA | cssl:d825 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:193517 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131831 (1) | 3738 nt | ||
| Genomic | GenBank:CR626905 (2) | 201465 nt | ||
| Polypeptide | UniProtKB:A0A8M2B3P6 (1) | 1055 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Dries, R., Lange, A., Heiny, S., Berghaus, K.I., Bastmeyer, M., Bentrop, J. (2021) Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Frontiers in cell and developmental biology. 8:591011
- Mitchell, D.M., Sun, C., Hunter, S.S., New, D.D., Stenkamp, D.L. (2019) Regeneration associated transcriptional signature of retinal microglia and macrophages. Scientific Reports. 9:4768
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Sun, C., Galicia, C., Stenkamp, D.L. (2018) Transcripts within rod photoreceptors of the Zebrafish retina. BMC Genomics. 19:127
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Thomas-Jinu, S., Gordon, P.M., Fielding, T., Taylor, R., Smith, B.N., Snowden, V., Blanc, E., Vance, C., Topp, S., Wong, C.H., Bielen, H., Williams, K.L., McCann, E.P., Nicholson, G.A., Pan-Vazquez, A., Fox, A.H., Bond, C.S., Talbot, W.S., Blair, I.P., Shaw, C.E., Houart, C. (2017) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Neuron. 94(2):322-336.e5
- Aleksejeva, E., Houel, A., Briolat, V., Levraud, J.P., Langevin, C., Boudinot, P. (2016) Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Developmental and comparative immunology. 57:48-56
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hörnberg, H., Cioni, J.M., Harris, W.A., Holt, C.E. (2016) Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:12697-12706
1 - 10 of 23
Show