Gene
mpz
- ID
- ZDB-GENE-010724-4
- Name
- myelin protein zero
- Symbol
- mpz Nomenclature History
- Previous Names
-
- p0
- sc:d0186
- wu:fc04b11
- wu:fi30g06
- zgc:103775
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in cell-cell adhesion via plasma-membrane adhesion molecules and myelination. Located in myelin sheath. Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple). Orthologous to human MPZ (myelin protein zero).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103775 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa62 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease dominant intermediate D | Alliance | Charcot-Marie-Tooth disease, dominant intermediate D | 607791 |
| Charcot-Marie-Tooth disease type 1B | Alliance | Charcot-Marie-Tooth disease, type 1B | 118200 |
| Charcot-Marie-Tooth disease type 2I | Alliance | Charcot-Marie-Tooth disease, type 2I | 607677 |
| Charcot-Marie-Tooth disease type 2J | Alliance | Charcot-Marie-Tooth disease, type 2J | 607736 |
| Charcot-Marie-Tooth disease type 3 | Alliance | Dejerine-Sottas disease | 145900 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin V-set domain | Myelin P0 protein, Ig-like domain | Myelin P0 protein-related |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QN30 | InterPro | 228 | |||||||
| UniProtKB:Q8JFG6 | InterPro | 203 | |||||||
| UniProtKB:A0A0R4IS04 | InterPro | 212 | |||||||
| UniProtKB:A0A8M6Z0S2 | InterPro | 206 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(mpz:mpz-EGFP) |
|
|
| 4 | (2) |
| Tg2(mpz:mpz-EGFP) |
|
|
| 1 | (2) |
| Tg3(mpz:mpz-EGFP) |
|
|
| 1 | (2) |
| Tg4(mpz:mpz-EGFP) |
|
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-35B8 | ZFIN Curated Data | |
| Contains | SNP | rs3727652 | ZFIN Curated Data | |
| Encodes | EST | fc04b11 | ZFIN Curated Data | |
| Encodes | EST | fi30g06 | Rajarao et al., 2001 | |
| Encodes | cDNA | cssl:d186 | Bushell et al., 2007 | |
| Encodes | cDNA | cssl:d806 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:103775 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191219 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194361 (1) | 2337 nt | ||
| Genomic | GenBank:AL935192 (1) | 192649 nt | ||
| Polypeptide | UniProtKB:A0A2R8QN30 (1) | 228 aa |
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Deng, J., Wang, Y., Hu, M., Lin, J., Li, Q., Liu, C., Xu, X. (2022) Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism. Frontiers in molecular neuroscience. 15:904935
- Jaronen, M., Wheeler, M.A., Quintana, F.J. (2022) Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish. STAR protocols. 3:101134
- Spencer, S.A., Suárez-Pozos, E., Verdugo, J.S., Wang, H., Afshari, F.S., Guo, L., Manam, S., Yasuda, D., Ortega, A., Lister, J.A., Ishii, S., Zhang, Y., Fuss, B. (2022) Lysophosphatidic acid signaling via LPA6 : a negative modulator of developmental oligodendrocyte maturation. Journal of neurochemistry. 163(6):478-499
- Brown, T.L., Hashimoto, H., Finseth, L.T., Wood, T.L., Macklin, W.B. (2021) PAK1 positively regulates oligodendrocyte morphology and myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(9):1864-1877
- Farías-Serratos, B.M., Lazcano, I., Villalobos, P., Darras, V.M., Orozco, A. (2021) Thyroid hormone deficiency during zebrafish development impairs central nervous system myelination. PLoS One. 16:e0256207
- Lu, S., Lyu, Z., Wang, Z., Kou, Y., Liu, C., Li, S., Hu, M., Zhu, H., Wang, W., Zhang, C., Kuan, Y.S., Liu, Y.W., Chen, J., Tian, J. (2021) Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 11:2788-2805
- Raas, Q., van de Beek, M.C., Forss-Petter, S., Dijkstra, I.M., DeSchiffart, A., Freshner, B.C., Stevenson, T.J., Jaspers, Y.R., Nagtzaam, L.M., Wanders, R.J., van Weeghel, M., Engelen-Lee, J.Y., Engelen, M., Eichler, F., Berger, J., Bonkowsky, J.L., Kemp, S. (2021) Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. The Journal of Clinical Investigation. 131(8):
- Siems, S.B., Jahn, O., Hoodless, L.J., Jung, R.B., Hesse, D., Möbius, W., Czopka, T., Werner, H.B. (2021) Proteome Profile of Myelin in the Zebrafish Brain. Frontiers in cell and developmental biology. 9:640169
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