Gene

dusp5

ID
ZDB-GENE-010625-1
Name
dual specificity phosphatase 5
Symbol
dusp5 Nomenclature History
Previous Names
  • wu:fc03b11
  • wu:fc86e02
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of MAPK cascade; and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; brain; intermediate cell mass of mesoderm; mesoderm; and vasculature. Orthologous to human DUSP5 (dual specificity phosphatase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
No data available
Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-dusp5N/APramanik et al., 2009
MO2-dusp5N/APramanik et al., 2009
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Human Disease
Associated With dusp5 Human Ortholog
No data available
Associated With dusp5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000340 Dual specificity phosphatase, catalytic domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR001763 Rhodanese-like domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
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Domain Details Per Protein
Protein Additional Resources Length Dual specificity phosphatase, catalytic domain Dual specificity protein phosphatase domain Mitogen-activated protein (MAP) kinase phosphatase Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like Rhodanese-like domain Rhodanese-like domain superfamily Tyrosine-specific protein phosphatases domain
UniProtKB:Q6PBT4 InterPro 368
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 22
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dusp5-201 (1) Ensembl 1,522 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-91I13ZFIN Curated Data
Contained inBACCH211-194K1ZFIN Curated Data
Contained inBACDKEY-262O11ZFIN Curated Data
EncodesESTfc03b11
EncodesESTfc86e02
EncodescDNAMGC:73256ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanDUSP510
Conserved genome location (synteny) (2)
Amino acid sequence comparison (2)
MouseDusp519
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
1 - 10 of 24
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