Gene
dusp5
- ID
- ZDB-GENE-010625-1
- Name
- dual specificity phosphatase 5
- Symbol
- dusp5 Nomenclature History
- Previous Names
-
- wu:fc03b11
- wu:fc86e02
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in endoderm formation; negative regulation of MAPK cascade; and signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including angioblastic mesenchymal cell; brain; intermediate cell mass of mesoderm; mesoderm; and vasculature. Orthologous to human DUSP5 (dual specificity phosphatase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73256 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-dusp5 | N/A | Pramanik et al., 2009 |
MO2-dusp5 | N/A | Pramanik et al., 2009 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR001763 | Rhodanese-like domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
1 - 5 of 9 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PBT4 | InterPro | 368 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-91I13 | ZFIN Curated Data | |
Contained in | BAC | CH211-194K1 | ZFIN Curated Data | |
Contained in | BAC | DKEY-262O11 | ZFIN Curated Data | |
Encodes | EST | fc03b11 | ||
Encodes | EST | fc86e02 | ||
Encodes | cDNA | MGC:73256 | ZFIN Curated Data |
1 - 6 of 6
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_212565 (1) | 1541 nt | ||
Genomic | GenBank:BX649552 | 163544 nt | ||
Polypeptide | UniProtKB:Q6PBT4 (1) | 368 aa |
- De Simone, A., Evanitsky, M.N., Hayden, L., Cox, B.D., Wang, J., Tornini, V.A., Ou, J., Chao, A., Poss, K.D., Di Talia, S. (2021) Control of osteoblast regeneration by a train of Erk activity waves. Nature. 590(7844):129-133
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Huang, W., Zheng, S., Xiao, J., Liu, C., Du, T., Wu, K. (2020) Parental exposure to bisphenol A affects pharyngeal cartilage development and causes global transcriptomic changes in zebrafish (Danio rerio) offspring. Chemosphere. 249:126537
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Fish, J.E., Cantu Gutierrez, M., Dang, L.T., Khyzha, N., Chen, Z., Veitch, S., Cheng, H.S., Khor, M., Antounians, L., Njock, M.S., Boudreau, E., Herman, A.M., Rhyner, A.M., Ruiz, O.E., Eisenhoffer, G.T., Medina-Rivera, A., Wilson, M.D., Wythe, J.D. (2017) Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development (Cambridge, England). 144:2428-2444
- Quillien, A., Abdalla, M., Yu, J., Ou, J., Zhu, L.J., Lawson, N.D. (2017) Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Reports. 20:709-720
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Wu, M., Liu, S., Hu, L., Qu, H., Pan, C., Lei, P., Shen, Y., Yang, M. (2017) Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquatic toxicology (Amsterdam, Netherlands). 192:274-283
- Faltermann, S., Grundler, V., Gademann, K., Pernthaler, J., Fent, K. (2016) Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquatic toxicology (Amsterdam, Netherlands). 171:77-87
- Faltermann, S., Hutter, S., Christen, V., Hettich, T., Fent, K. (2016) Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio). toxins. 8(7)
1 - 10 of 24
Show