Gene
cp
- ID
- ZDB-GENE-010522-1
- Name
- ceruloplasmin
- Symbol
- cp Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including blood plasma; digestive system; liver and biliary system; male organism; and yolk syncytial layer. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 99 figures from 64 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55445 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Choksi et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa30734 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| aceruloplasminemia | Alliance | Aceruloplasminemia | 604290 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR002355 | Multicopper oxidase, copper-binding site |
| Conserved_site | IPR033138 | Multicopper oxidases, conserved site |
| Domain | IPR011706 | Multicopper oxidase, C-terminal |
| Domain | IPR011707 | Multicopper oxidase-like, N-terminal |
| Domain | IPR048236 | Ceruloplasmin-like, fifth cupredoxin domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ceruloplasmin-like, fifth cupredoxin domain | Cupredoxin | Multicopper oxidase | Multicopper oxidase, copper-binding site | Multicopper oxidase, C-terminal | Multicopper oxidase-like, N-terminal | Multicopper oxidases, conserved site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU12 | InterPro | 1087 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284E20 | ZFIN Curated Data | |
| Contains | STS | chunp40190 | ||
| Encodes | EST | fi23f10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55445 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77935 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131802 (1) | 3370 nt | ||
| Genomic | GenBank:AL954145 (1) | 160871 nt | ||
| Polypeptide | UniProtKB:Q7ZU12 (1) | 1087 aa |
- Gang, K., Chen, Q., Sun, J., Zhang, T., Cai, P., Ni, R., Ma, J. (2025) Khdrbs1 drives redifferentiation of bipotential progenitor cell by inhibiting p53 in zebrafish biliary-mediated liver regeneration. Development (Cambridge, England). :
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Hu, Y., Luo, Z., Wang, M., Wu, Z., Liu, Y., Cheng, Z., Sun, Y., Xiong, J.W., Tong, X., Zhu, Z., Zhang, B. (2024) Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 52(1):66-77
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Cao, P., Cheng, Y., Li, Z., Cheng, Y.J., Chu, X., Geng, C., Yin, X., Li, Y. (2023) Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration. Journal of nanobiotechnology. 21:4444
- Feng, J., Chen, X., Wang, S., Zhang, J., Wang, Q., Guo, S., Shen, Q. (2023) Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish. Food & function. 14(8):3641-3658
- Jin, Q., Hu, Y., Gao, Y., Zheng, J., Chen, J., Gao, C., Peng, J. (2023) Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish. Biochemical and Biophysical Research Communications. 686:149182149182
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
- Pereiro, P., Rey-Campos, M., Figueras, A., Novoa, B. (2023) An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection. Frontiers in immunology. 13:11000921100092
- Rizvi, F., Lee, Y.R., Diaz-Aragon, R., Bawa, P.S., So, J., Florentino, R.M., Wu, S., Sarjoo, A., Truong, E., Smith, A.R., Wang, F., Everton, E., Ostrowska, A., Jung, K., Tam, Y., Muramatsu, H., Pardi, N., Weissman, D., Soto-Gutierrez, A., Shin, D., Gouon-Evans, V. (2023) VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis. Cell Stem Cell. 30(12):1640-1657.e8
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