Gene
cry2
- ID
- ZDB-GENE-010426-6
- Name
- cryptochrome circadian regulator 2
- Symbol
- cry2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity and FAD binding activity. Acts upstream of or within negative regulation of DNA-templated transcription; response to light stimulus; and response to temperature stimulus. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; eye; inner ear; liver; and pleuroperitoneal region. Orthologous to human CRY2 (cryptochrome circadian regulator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56341 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zju132 | Allele with one insertion | Exon 5 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cry2 | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005101 | Cryptochrome/DNA photolyase, FAD-binding domain |
| Domain | IPR006050 | DNA photolyase, N-terminal |
| Family | IPR002081 | Cryptochrome/DNA photolyase class 1 |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036134 | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cryptochrome/DNA photolyase class 1 | Cryptochrome/DNA photolyase, FAD-binding domain | Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily | Cryptochrome/photolyase, N-terminal domain superfamily | DNA photolyase, N-terminal | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZU53 | InterPro | 598 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160M17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-28J3 | ZFIN Curated Data | |
| Encodes | EST | fe16d07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56341 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131786 (1) | 2069 nt | ||
| Genomic | GenBank:AL844193 | 210900 nt | ||
| Polypeptide | UniProtKB:Q7ZU53 (1) | 598 aa |
- Zhao, W., Mao, L., He, C., Ding, D., Hu, N., Song, X., Long, D. (2023) Effects of low dose radiation on behavior rhythm of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 255:114779114779
- Nakagawa, M., Okano, K., Saratani, Y., Shoji, Y., Okano, T. (2022) Midnight/midday-synchronized expression of cryptochrome genes in the eyes of three teleost species, zebrafish, goldfish, and medaka. Zoological letters. 8:8
- Bolton, C.M., Bekaert, M., Eilertsen, M., Helvik, J.V., Migaud, H. (2021) Rhythmic Clock Gene Expression in Atlantic Salmon Parr Brain. Frontiers in Physiology. 12:761109
- Iida, M., Nakane, Y., Yoshimura, T., Hirota, T. (2021) Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish. Journal of biochemistry. 171(5):501-507
- Safarian, N., Houshangi-Tabrizi, S., Zoidl, C., Zoidl, G.R. (2021) Panx1b Modulates the Luminance Response and Direction of Locomotion in the Zebrafish. International Journal of Molecular Sciences. 22(21):
- Balay, S.D., Widen, S.A., Waskiewicz, A.J. (2020) Analysis of zebrafish Cryptochrome 2 and 4 expression in UV cone photoreceptors. Gene expression patterns : GEP. 35:119100
- Okano, K., Saratani, Y., Tamasawa, A., Shoji, Y., Toda, R., Okano, T. (2020) A photoperiodic time measurement served by the biphasic expression of Cryptochrome1ab in the zebrafish eye. Scientific Reports. 10:5056
- Hirayama, J., Alifu, Y., Hamabe, R., Yamaguchi, S., Tomita, J., Maruyama, Y., Asaoka, Y., Nakahama, K.I., Tamaru, T., Takamatsu, K., Takamatsu, N., Hattori, A., Nishina, S., Azuma, N., Kawahara, A., Kume, K., Nishina, H. (2019) The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Scientific Reports. 9:196
- Liang, Y.Q., Huang, G.Y., Zhen, Z., Tian, F., Hou, L., Lin, Z., Ying, G.G. (2019) The effects of binary mixtures of estradiol and progesterone on transcriptional expression profiles of genes involved in hypothalamic-pituitary-gonadal axis and circadian rhythm signaling in embryonic zebrafish (Danio rerio). Ecotoxicology and environmental safety. 174:540-548
- Yang, Y., Dong, F., Liu, X., Xu, J., Wu, X., Zheng, Y. (2019) Dysregulation of circadian rhythm in zebrafish (Danio rerio) by thifluzamide: Involvement of positive and negative regulators. Chemosphere. 235:280-287
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