Gene
ctbp2a
- ID
- ZDB-GENE-010130-2
- Name
- C-terminal binding protein 2a
- Symbol
- ctbp2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including nervous system development; regulation of gliogenesis; and regulation of melanocyte differentiation. Predicted to be located in synapse. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77268 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la020241Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020242Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nk17bEt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa297 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10746 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12314 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17809 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23003 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30695 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa32122 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ctbp2a | N/A | (2) |
| MO2-ctbp2a | N/A | (2) |
| MO3-ctbp2a | N/A | Liang et al., 2011 |
| MO4-ctbp2a | N/A | Liang et al., 2011 |
| MO5-ctbp2a | N/A | Salta et al., 2014 |
| MO6-ctbp2a | N/A | Salta et al., 2014 |
| MO7-ctbp2a | N/A | Salta et al., 2014 |
| MO8-ctbp2a | N/A | Salta et al., 2014 |
| MO9-ctbp2a | N/A | Salta et al., 2014 |
| MO10-ctbp2a | N/A | Sertori et al., 2025 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR043322 | C-terminal binding protein |
| Family | IPR051638 | C-terminal-binding dehydrogenase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C-terminal-binding dehydrogenase | C-terminal binding protein | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5BU19 | InterPro | 1147 | ||||||
| UniProtKB:Q9DEG6 | InterPro | 444 | ||||||
| UniProtKB:A0AB32T3T5 | InterPro | 435 | ||||||
| UniProtKB:A0AB32T658 | InterPro | 1240 | ||||||
| UniProtKB:A0AB32T7H4 | InterPro | 1200 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctbp2a-201
(1)
|
Ensembl | 3,746 nt | ||
| mRNA |
ctbp2a-202
(1)
|
Ensembl | 3,447 nt | ||
| mRNA |
ctbp2a-203
(1)
|
Ensembl | 3,035 nt | ||
| mRNA |
ctbp2a-204
(1)
|
Ensembl | 3,471 nt | ||
| mRNA |
ctbp2a-205
(1)
|
Ensembl | 825 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| AB2-ctbp2a | Chicken |
|
1 | ||||
| Ab1-ctbp2a | polyclonal | Rabbit |
|
10 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.8ctbp2a:clta-EGFP) |
|
| 1 | (2) | |
| Tg(-1.8ctbp2a:clta-mCherry) |
|
| 1 | (2) | |
| Tg(-1.8ctbp2a:dnm2a-EGFP) |
|
| 1 | (2) | |
| Tg(-1.8ctbp2a:GAL4-VP16,myl7:mCherry) |
|
| 1 | (2) | |
| Tg(-1.8ctbp2a:GAP-EGFP) |
|
| 1 | (5) | |
| Tg(-1.8ctbp2a:mCherry-ctbp2a) |
|
|
| 1 | (3) |
| Tg(-1.8ctbp2a:Rno.Syp-GCaMP2) |
|
| 1 | (12) | |
| Tg(-1.8ctbp2a:Rno.Syp-GCaMP6) |
|
| 1 | (6) | |
| Tg(-1.8ctbp2a:Rno.Syp-GCaMP7b) |
|
| 1 | Bartel et al., 2021 | |
| Tg(-1.8ctbp2a:sypb-EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-108I17 | ZFIN Curated Data | |
| Encodes | EST | fe05b01 | ZFIN Curated Data | |
| Encodes | EST | fk19e02 | ||
| Encodes | cDNA | MGC:55495 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65878 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77268 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77355 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175158 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191960 | ZFIN Curated Data | |
| Has Artifact | EST | fb96g03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001195491 (1) | 3857 nt | ||
| Genomic | GenBank:CU459182 (2) | 142261 nt | ||
| Polypeptide | UniProtKB:A0AB32T658 (1) | 1240 aa |
- Sertori, R., Truong, B., Singh, M.K., Shinton, S., Price, R., Sharo, A., Shultes, P., Sunderam, U., Rana, S., Srinivasan, R., Datta, S., Font-Burgada, J., Brenner, S.E., Puck, J.M., Wiest, D.L. (2025) Disruption of the moonlighting function of CTF18 in a patient with T-lymphopenia. Frontiers in immunology. 16:15398481539848
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Shrestha, A.P., Saravanakumar, A., Konadu, B., Madireddy, S., Gibert, Y., Vaithianathan, T. (2022) Embryonic Hyperglycemia Delays the Development of Retinal Synapses in a Zebrafish Model. International Journal of Molecular Sciences. 23(17)
- Bartel, P., Yoshimatsu, T., Janiak, F.K., Baden, T. (2021) Spectral inference reveals principal cone-integration rules of the zebrafish inner retina. Current biology : CB. 31(23):5214-5226.e4
- Manchanda, A., Bonventre, J.A., Bugel, S.M., Chatterjee, P., Tanguay, R., Johnson, C.P. (2021) Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking. Molecular biology of the cell. 32(14):1293-1305
- Shi, W.J., Huang, G.Y., Jiang, Y.X., Ma, D.D., Chen, H.X., Huang, M.Z., Hou, L.P., Xie, L., Ying, G.G. (2020) Medroxyprogesterone acetate affects eye growth and the transcription of associated genes in zebrafish. Ecotoxicology and environmental safety. 193:110371
- James, B., Darnet, L., Moya-Díaz, J., Seibel, S.H., Lagnado, L. (2019) An amplitude code transmits information at a visual synapse. Nature Neuroscience. 22(7):1140-1147
- Manchanda, A., Chatterjee, P., Bonventre, J.A., Haggard, D.E., Kindt, K.S., Tanguay, R.L., Johnson, C.P. (2019) Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Scientific Reports. 9:14273
- Wong, H.C., Zhang, Q., Beirl, A.J., Petralia, R.S., Wang, Y.X., Kindt, K. (2019) Synaptic mitochondria regulate hair-cell synapse size and function. eLIFE. 8:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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