Gene
klf17
- ID
- ZDB-GENE-010129-1
- Name
- Kruppel like factor 17
- Symbol
- klf17 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Acts upstream of or within several processes, including hatching gland development; regulation of gene expression; and regulation of primitive erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; germ ring; hematopoietic system; lateral line system; and mesoderm. Orthologous to human KLF17 (KLF transcription factor 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109839 (34 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9224 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39866 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39867 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uy21 | Allele with one delins | Unknown | Unknown | CRISPR | |
| uy22 | Allele with one delins | Unknown | Unknown | CRISPR | |
| uy23 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:Q9DFS2 | InterPro | 409 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-45G1 | ZFIN Curated Data | |
| Encodes | EST | fc09b11 | ZFIN Curated Data | |
| Encodes | EST | ibd5109 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_1b8 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_1e5 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_1e12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109839 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192869 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131723 (1) | 1642 nt | ||
| Genomic | GenBank:BX649271 (2) | 22848 nt | ||
| Polypeptide | UniProtKB:Q9DFS2 (1) | 409 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Oates et al. (2001) ZDB-PUB-010912-8 originally classified this gene as an orthologue of mammalian KLF4, based on amino acid sequence homology. A more complete analysis in Kotkamp et al. (2014) ZDB-PUB-131218-14 presented synteny evidence supporting orthology to mammalian KLF17 genes.
- Hadzhiev, Y., Wheatley, L., Cooper, L., Ansaloni, F., Whalley, C., Chen, Z., Finaurini, S., Gustincich, S., Sanges, R., Burgess, S., Beggs, A., Müller, F. (2023) The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation. Developmental Cell. 58:155170.e8155-170.e8
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
- Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
- Kontur, C., Jeong, M., Cifuentes, D., Giraldez, A.J. (2020) Ythdf m6A Readers Function Redundantly during Zebrafish Development. Cell Reports. 33:108598
- Liu, H., Duncan, K., Helverson, A., Kumari, P., Mumm, C., Xiao, Y., Carlson, J.C., Darbellay, F., Visel, A., Leslie, E., Breheny, P., Erives, A.J., Cornell, R.A. (2020) Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. eLIFE. 9:
- Raj, B., Farrell, J.A., Liu, J., El Kholtei, J., Carte, A.N., Navajas Acedo, J., Du, L.Y., McKenna, A., Relić, Đ., Leslie, J.M., Schier, A.F. (2020) Emergence of Neuronal Diversity during Vertebrate Brain Development. Neuron. 108(6):1058-1074.e6
- Akthar, I.S.T., Pichiah, P.B.T., Arunachalam, S., Raja, S. (2019) Adriamycin inhibits embryonic development in zebrafish through downregulation of Kruppel-like factor4. Journal of biochemical and molecular toxicology. :e22235
- Kobayashi, I., Kobayashi-Sun, J., Hirakawa, Y., Ouchi, M., Yasuda, K., Kamei, H., Fukuhara, S., Yamaguchi, M. (2019) Dual role of Jam3b in early hematopoietic and vascular development. Development (Cambridge, England). 147(1):
- Suzuki, H., Ishizaka, T., Yanagi, K., Sone, R., Sunaga, Y., Ohga, R., Kawahara, A. (2019) Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development. Scientific Reports. 9:13680
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