Gene
arnt2
- ID
- ZDB-GENE-001207-3
- Name
- aryl-hydrocarbon receptor nuclear translocator 2
- Symbol
- arnt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Involved in regulation of DNA-templated transcription; response to hypoxia; and signal transduction. Acts upstream of or within several processes, including nervous system development; positive regulation of hypoxia-inducible factor-1alpha signaling pathway; and swim bladder inflation. Predicted to be located in cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Is expressed in several structures, including gut; hatching gland; mandibular arch skeleton; nervous system; and vasculature. Orthologous to human ARNT2 (aryl hydrocarbon receptor nuclear translocator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bcm3 | Allele with one delins | Unknown | Unknown | CRISPR | |
| hi1715Tg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| hi2639cTg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| la025771Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m1055 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11162 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15572 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20863 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20864 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20865 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-arnt2 | Marchi et al., 2020 | |
| CRISPR2-arnt2 | Marchi et al., 2020 | |
| CRISPR3-arnt2 | Marchi et al., 2020 | |
| CRISPR4-arnt2 | Marchi et al., 2020 | |
| CRISPR5-arnt2 | Edwards et al., 2023 | |
| MO1-arnt2 | N/A | (2) |
| MO2-arnt2 | N/A | (2) |
| MO3-arnt2 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Webb-Dattani syndrome | 615926 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Circadian Clock Transcription Factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B3V4 | InterPro | 723 | ||||||||
| UniProtKB:Q9DG12 | InterPro | 737 | ||||||||
| UniProtKB:A0A0R4ID51 | InterPro | 722 | ||||||||
| UniProtKB:A0A8M3ATW0 | InterPro | 738 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-arnt2 | monoclonal | IgG1 | Mouse |
|
Affinity BioReagents (Thermo Fisher Scientific)
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-268O14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-204O5 | ZFIN Curated Data | |
| Encodes | STS | chunp6921 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131674 (1) | 2294 nt | ||
| Genomic | GenBank:BX936312 (1) | 158510 nt | ||
| Polypeptide | UniProtKB:A0A8M3ATW0 (1) | 738 aa |
- Li, S., Li, H., Bennewitz, K., Poschet, G., Buettner, M., Hausser, I., Szendroedi, J., Nawroth, P.P., Kroll, J. (2025) Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis. Metabolism: clinical and experimental. :156149156149
- Chen, F., Pu, S., Tian, L., Zhang, H., Zhou, H., Yan, Y., Hu, X., Wu, Q., Chen, X., Cheng, S.H., Xu, S. (2024) Radix Rehmanniae Praeparata promoted zebrafish fin regeneration through aryl hydrocarbon receptor-dependent autophagy. Journal of ethnopharmacology. 331:118272
- Edwards, H.E., Edgington, M.J., Souder, J.P., Gorelick, D.A. (2023) Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. Development (Cambridge, England). 150(9)
- Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249
- Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
- Meng, Q., Yeung, K., Kwok, M.L., Chung, C.T., Hu, X.L., Chan, K.M. (2020) Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones. Environmental pollution (Barking, Essex : 1987). 265:114857
- Smirnova, A., Mentor, A., Ranefall, P., Bornehag, C.G., Brunström, B., Mattsson, A., Jönsson, M. (2020) Increased apoptosis, reduced Wnt/β-catenin signaling, and altered tail development in zebrafish embryos exposed to a human-relevant chemical mixture. Chemosphere. 264:128467
- Mentor, A., Brunström, B., Mattsson, A., Jönsson, M. (2019) Developmental exposure to a human relevant mixture of endocrine disruptors alters metabolism and adipogenesis in zebrafish (Danio rerio). Chemosphere. 238:124584
- Salanga, M.C., Brun, N.R., Francolini, R.D., Stegeman, J.J., Goldstone, J.V. (2019) CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish (Danio rerio) larvae. Toxicological sciences : an official journal of the Society of Toxicology. 174(1):51-62
- Chen, Y.Y., Chan, K.M. (2018) Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+in vivo.. Chemosphere. 210:577-587
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