Gene
supt5h
- ID
- ZDB-GENE-001207-1
- Name
- SPT5 homolog, DSIF elongation factor subunit
- Symbol
- supt5h Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Acts upstream of or within several processes, including generation of neurons; regulation of signal transduction; and regulation of transcription elongation by RNA polymerase II. Located in nucleus. Is expressed in brain; optic cup; and telencephalon. Orthologous to human SUPT5H (SPT5 homolog, DSIF elongation factor subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66413 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh20 | Allele with one point mutation | Unknown | Cryptic Splice Site | not specified | |
| la012689Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m806 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa13309 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42529 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sk8 | Allele with one point mutation | Unknown | Cryptic Donor Splice Site, Exon Loss, Frameshift, Premature Stop | not specified |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-supt5h | N/A | Bai et al., 2010 |
| MO2-supt5h | N/A | Taneda et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | KOW | Large ribosomal subunit protein uL2, domain 2 | NGN domain | NGN domain, eukaryotic | NusG-like, N-terminal | NusG, N-terminal domain superfamily | Spt5 C-terminal domain | Spt5, KOW domain repeat 1 | Spt5, KOW domain repeat 2 | Spt5, KOW domain repeat 3 | Spt5, KOW domain repeat 4 | Spt5, KOW domain repeat 5 | Spt5, KOW domain repeat 6 | Spt5 transcription elongation factor, N-terminal | Transcription elongation factor SPT5 | Transcription elongation factor Spt5, eukaryote | Translation protein SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DDT5 | InterPro | 1084 | |||||||||||||||||
| UniProtKB:A0A8M9Q0J3 | InterPro | 1086 | |||||||||||||||||
| UniProtKB:A0A8M1P6F8 | InterPro | 1084 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
supt5h-201
(1)
|
Ensembl | 3,868 nt | ||
| mRNA |
supt5h-202
(1)
|
Ensembl | 4,024 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-supt5h | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-46I14 | ZFIN Curated Data | |
| Contains | SNP | rs3728709 | ZFIN Curated Data | |
| Encodes | EST | fb37g01 | ZFIN Curated Data | |
| Encodes | EST | fb95e05 | ZFIN Curated Data | |
| Encodes | EST | fc10f02 | ||
| Encodes | cDNA | MGC:66413 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131673 (1) | 3861 nt | ||
| Genomic | GenBank:CR626887 (1) | 198090 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0J3 (1) | 1086 aa |
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Liu, Q., Klingler, R.H., Wimpee, B., Dellinger, M., King-Heiden, T., Grzybowski, J., Gerstenberger, S.L., Weber, D.N., Caravan, M.J. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:272-282
- Yang, Q., Liu, X., Zhou, T., Cook, J., Nguyen, K., Bai, X. (2016) RNA polymerase II pausing differentially regulates signaling pathway genes to control hematopoietic stem cell emergence in zebrafish. Blood. 128(13):1701-10
- Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Taneda, T., Zhu, W., Cao, Q., Watanabe, H., Yamaguchi, Y., Handa, H., and Wada, T. (2011) Erythropoiesis is regulated by the transcription elongation factor Foggy/Spt5 through gata1 gene regulation. Genes to cells : devoted to molecular & cellular mechanisms. 16(2):231-242
- White, R.M., Cech, J., Ratanasirintrawoot, S., Lin, C.Y., Rahl, P.B., Burke, C.J., Langdon, E., Tomlinson, M.L., Mosher, J., Kaufman, C., Chen, F., Long, H.K., Kramer, M., Datta, S., Neuberg, D., Granter, S., Young, R.A., Morrison, .S, Wheeler, G.N., and Zon, L.I. (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471(7339):518-522
- Bai, X., Kim, J., Yang, Z., Jurynec, M.J., Akie, T.E., Lee, J., LeBlanc, J., Sessa, A., Jiang, H., DiBiase, A., Zhou, Y., Grunwald, D.J., Lin, S., Cantor, A.B., Orkin, S.H., and Zon, L.I. (2010) TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142(1):133-143
- Chen, H., Contreras, X., Yamaguchi, Y., Handa, H., Peterlin, B.M., and Guo, S. (2009) Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. PLoS One. 4(9):e6918
- Krishnan, K., Salomonis, N., and Guo, S. (2008) Identification of Spt5 target genes in zebrafish development reveals its dual activity in vivo. PLoS One. 3(11):e3621
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