Gene

csf1ra

ID
ZDB-GENE-001205-1
Name
colony stimulating factor 1 receptor, a
Symbol
csf1ra Nomenclature History
Previous Names
  • c-fms (1)
  • csf1r
  • fms (1)
  • pfe (1)
  • sal (1)
  • salz (1)
  • panther
  • pfeffer (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable growth factor binding activity and macrophage colony-stimulating factor receptor activity. Acts upstream of or within several processes, including immune response in brain or nervous system; macrophage chemotaxis; and myeloid cell development. Predicted to be located in membrane. Predicted to be part of CSF1-CSF1R complex and receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; integument; and neural crest cell. Used to study CSF1R-related brain malformation and osteopetrosis. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; diabetes mellitus; gastrointestinal system cancer (multiple); lung cancer (multiple); and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
88 figures from 63 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
66 figures from 28 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
csf1ra_unspecifiedUnspecified AlleleUnknownUnknownnot specified
j4blueAllele with one deletionUnknownFrameshift, Premature Stopnot specified
j4e1Allele with one point mutationUnknownMissenseENU
j4e2Allele with one point mutationUnknownMissenseENU
mh5unknownUnknownUnknownENU
nku3Allele with one delinsUnknownUnknownCRISPR
re25Allele with one point mutationUnknownUnknownCRISPR
re26Allele with one deletionUnknownUnknownCRISPR
sa9484Allele with one point mutationUnknownSplice SiteENU
sa15067Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Human Disease
Associated With csf1ra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia Alliance Leukoencephalopathy, diffuse hereditary, with spheroids 1 221820
Brain abnormalities, neurodegeneration, and dysosteosclerosis 618476
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Associated With csf1ra Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
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Domain Details Per Protein
Protein Additional Resources Length Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype 2 Macrophage colony-stimulating factor 1 receptor Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor Tyrosine Kinase Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site
UniProtKB:B3DHL0 InterPro 977
UniProtKB:A0A8M9QKN6 InterPro 977
UniProtKB:Q9I8N6 InterPro 977
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 14
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA csf1ra-201 (1) Ensembl 3,459 nt
mRNA csf1ra-203 (1) Ensembl 3,522 nt
mRNA csf1ra-204 (1) Ensembl 3,004 nt
ncRNA csf1ra-002 (1) Ensembl 2,788 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-csf1ra polyclonal IgG Rabbit
  • WB
AnaSpec
3
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(csf1ra:GAL4-VP16)
  • csf1ra
  • Danio rerio
1 (43)
TgBAC(csf1ra:GFP)
  • csf1ra
  • Danio rerio
1 (7)
Tg(csf1ra-E1B:GFP)
  • Danio rerio
1Caetano-Lopes et al., 2020
Tg(mpeg1.1:csf1ra)
  • csf1ra
  • Danio rerio
1Yu et al., 2023
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inFosmidCH1073-425O22ZFIN Curated Data
Contained inFosmidZFOS-1069F5ZFIN Curated Data
EncodescDNAcssl:d116Bushell et al., 2007
EncodescDNAMGC:194643ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCSF1R5
Phylogenetic tree (1)
Amino acid sequence comparison (4)
Nucleotide sequence comparison (1)
Conserved genome location (synteny) (1)
MouseCsf1r18
Phylogenetic tree (1)
Nucleotide sequence comparison (1)
Amino acid sequence comparison (4)
Citations
1 - 10 of 218
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