Gene

fezf2

ID
ZDB-GENE-001103-3
Name
FEZ family zinc finger 2
Symbol
fezf2 Nomenclature History
Previous Names
  • fez (1)
  • fezl
  • tof
  • foreheadin (1)
  • too few
  • zgc:92690
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including nervous system development; neuronal stem cell population maintenance; and regulation of Notch signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural keel; neural plate; neuroectoderm; and optic vesicle. Orthologous to human FEZF2 (FEZ family zinc finger 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 24 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
m808Allele with one point mutationExon 2MissenseENU
sa178Allele with one point mutationUnknownPremature StopENU
sa278Allele with one point mutationUnknownPremature StopENU
sa14758Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-fezf2N/A (3)
MO2-fezf2N/A (7)
MO3-fezf2N/ABlechman et al., 2007
MO4-fezf2N/A (2)
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Human Disease
Associated With fezf2 Human Ortholog
No data available
Associated With fezf2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
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Domain Details Per Protein
Protein Additional Resources Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A0A8M2B2Q7 InterPro 438
UniProtKB:Q804Q5 InterPro 430
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 11
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fezf2-201 (1) Ensembl 1,838 nt
mRNA fezf2-202 (1) Ensembl 1,645 nt
mRNA ottdart00000001837 (1) Havana 1,653 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fezf2 polyclonal Rabbit
  • WB
1
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Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg1(fezf2-E1B:EGFP)
  • Danio rerio
1 (2)
Tg2(fezf2-E1B:EGFP)
  • Danio rerio
1 (2)
Tg(fezf2:EGFP)
  • fezf2
  • Danio rerio
1 (5)
Tg(fezf2:GFP)
  • fezf2
  • Danio rerio
1 (5)
Tg(fezf2:mNeonGreen2-Split1-10)
  • fezf2
  • Danio rerio
1Ligunas et al., 2024
Tg(hsp70l:fezf2,EGFP)
  • Danio rerio
1 (2)
Tg(UAS:fezf2)
  • fezf2
  • Danio rerio
1 (5)
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-274M17ZFIN Curated Data
Contained inPACBUSM1-6A2ZFIN Curated Data
EncodesESTeu185
    Thisse et al., 2005
    EncodescDNAMGC:92690ZFIN Curated Data
    EncodescDNAMGC:192936ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanFEZF23
    Conserved genome location (synteny) (1)
    Amino acid sequence comparison (2)
    MouseFezf214
    Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Citations
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