Gene
fezf2
- ID
- ZDB-GENE-001103-3
- Name
- FEZ family zinc finger 2
- Symbol
- fezf2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Acts upstream of or within several processes, including nervous system development; neuronal stem cell population maintenance; and regulation of Notch signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural keel; neural plate; neuroectoderm; and optic vesicle. Orthologous to human FEZF2 (FEZ family zinc finger 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu185 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:A0A8M2B2Q7 | InterPro | 438 | ||
| UniProtKB:Q804Q5 | InterPro | 430 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(fezf2-E1B:EGFP) |
|
| 1 | (2) | |
| Tg2(fezf2-E1B:EGFP) |
|
| 1 | (2) | |
| Tg(fezf2:EGFP) |
|
| 1 | (5) | |
| Tg(fezf2:GFP) |
|
| 1 | (5) | |
| Tg(fezf2:mNeonGreen2-Split1-10) |
|
| 1 | Ligunas et al., 2024 | |
| Tg(hsp70l:fezf2,EGFP) |
|
| 1 | (2) | |
| Tg(UAS:fezf2) |
|
| 1 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-274M17 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-6A2 | ZFIN Curated Data | |
| Encodes | EST | eu185 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:92690 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192936 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131636 (1) | 1841 nt | ||
| Genomic | GenBank:BX276115 (2) | 87945 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2Q7 (1) | 438 aa |
- Ligunas, G.D., Paniagua, G., LaBelle, J., Ramos-Martinez, A., Shen, K., Gerlt, E.H., Aguilar, K., Nguyen, N., Materna, S.C., Woo, S. (2024) Tissue-specific and endogenous protein labeling with split fluorescent proteins. Developmental Biology. 514:109-116
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- He, L., Zhang, Q., Jiang, D., Zhang, Y., Wei, Y., Yang, Y., Li, N., Wang, S., Yue, Y., Zhao, Q. (2021) Zebrafish foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression. Journal of genetics and genomics = Yi chuan xue bao. 49(6):559-568
- Huang, C.X., Zhao, Y., Mao, J., Wang, Z., Xu, L., Cheng, J., Guan, N.N., Song, J. (2021) An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish. Nature communications. 12:7093
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Pei, D.S., Jia, P.P., Luo, J.J., Liu, W., Strauss, P.R. (2019) AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair. Cell Death & Disease. 10:348
- Farrell, J.A., Wang, Y., Riesenfeld, S.J., Shekhar, K., Regev, A., Schier, A.F. (2018) Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis. Science (New York, N.Y.). 360(6392)
- Spikol, E.D., Glasgow, E. (2018) Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression. Biology Open. 7(3)
- Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
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