Gene
cd74a
- ID
- ZDB-GENE-000901-1
- Name
- CD74 molecule, major histocompatibility complex, class II invariant chain a
- Symbol
- cd74a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within several processes, including T cell activation involved in immune response; dendritic cell antigen processing and presentation; and neuromast development. Located in cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77643 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
bns454 | Allele with one delins | Unknown | Unknown | CRISPR |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-cd74a | (2) | |
MO1-cd74a | N/A | Shen et al., 2012 |
MO2-cd74a | N/A | Serbanovic-Canic et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000716 | Thyroglobulin type-1 |
Domain | IPR015386 | MHC class II-associated invariant chain/CLIP, MHC II-interacting |
Family | IPR043530 | HLA class II histocompatibility antigen, gamma subunit |
Family | IPR051950 | Developmental regulator and protease inhibitor |
Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Developmental regulator and protease inhibitor | HLA class II histocompatibility antigen, gamma subunit | MHC class II-associated invariant chain/CLIP, MHC II-interacting | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:Q9PUT2 | InterPro | 237 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-201I24 | ZFIN Curated Data | |
Contains | SNP | rs3728618 | ZFIN Curated Data | |
Encodes | EST | fb11f09 | ZFIN Curated Data | |
Encodes | EST | fb12a01 | ZFIN Curated Data | |
Encodes | EST | fb13d06 | ZFIN Curated Data | |
Encodes | EST | fk94e07 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77643 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131590 (1) | 1149 nt | ||
Genomic | GenBank:CU468924 (1) | 159932 nt | ||
Polypeptide | UniProtKB:Q9PUT2 (1) | 237 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Bhattarai, P., Gunasekaran, T.I., Belloy, M.E., Reyes-Dumeyer, D., Jülich, D., Tayran, H., Yilmaz, E., Flaherty, D., Turgutalp, B., Sukumar, G., Alba, C., McGrath, E.M., Hupalo, D.N., Bacikova, D., Le Guen, Y., Lantigua, R., Medrano, M., Rivera, D., Recio, P., Nuriel, T., Ertekin-Taner, N., Teich, A.F., Dickson, D.W., Holley, S., Greicius, M., Dalgard, C.L., Zody, M., Mayeux, R., Kizil, C., Vardarajan, B.N. (2024) Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease. Acta Neuropathologica. 147:7070
- Cardeira-da-Silva, J., Wang, Q., Sagvekar, P., Mintcheva, J., Latting, S., Günther, S., Ramadass, R., Yekelchyk, M., Preussner, J., Looso, M., Junker, J.P., Stainier, D.Y.R. (2024) Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish. Nature communications. 15:36373637
- Cortada, E., Yao, J., Xia, Y., Dündar, F., Zumbo, P., Yang, B., Rubio-Navarro, A., Perder, B., Qiu, M., Pettinato, A.M., Homan, E.A., Stoll, L., Betel, D., Cao, J., Lo, J.C. (2024) Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury. Communications biology. 7:16111611
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Shao, T., Ji, J.F., Zheng, J.Y., Li, C., Zhu, L.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2022) Zbtb46 Controls Dendritic Cell Activation by Reprogramming Epigenetic Regulation of cd80/86 and cd40 Costimulatory Signals in a Zebrafish Model. Journal of immunology (Baltimore, Md. : 1950). 208(12):2686-2701
- Yu, F., Luo, H.R., Cui, X.F., Wu, Y.J., Li, J.L., Feng, W.R., Tang, Y.K., Su, S.Y., Xiao, J., Hou, Z.S., Xu, P. (2022) Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis. Ecotoxicology and environmental safety. 248:114303
- Ma, H., Liu, Z., Yang, Y., Feng, D., Dong, Y., Garbutt, T.A., Hu, Z., Wang, L., Luan, C., Cooper, C.D., Li, Y., Welch, J.D., Qian, L., Liu, J. (2021) Functional coordination of non-myocytes plays a key role in adult zebrafish heart regeneration. EMBO reports. 22(11):e52901
- Silva, N.J., Dorman, L.C., Vainchtein, I.D., Horneck, N.C., Molofsky, A.V. (2021) In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain. Nature communications. 12:5916
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