Gene
pcxb
- ID
- ZDB-GENE-000831-1
- Name
- pyruvate carboxylase b
- Symbol
- pcxb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate carboxylase activity. Acts upstream of or within response to cadmium ion. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sandoval et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026197Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12351 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21111 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34211 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pcxb | LaCoursiere et al., 2024 | |
| CRISPR2-pcxb | LaCoursiere et al., 2024 | |
| MO1-pcxb | N/A | Sandoval et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate carboxylase deficiency disease | Alliance | Pyruvate carboxylase deficiency | 266150 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR000891 | Pyruvate carboxyltransferase |
| Domain | IPR003379 | Carboxylase, conserved domain |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase-type TIM barrel | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Carboxylase, conserved domain | Pre-ATP-grasp domain superfamily | Pyruvate carboxylase | Pyruvate carboxylase-like | Pyruvate carboxyltransferase | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QYZ6 | InterPro | 1181 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194C5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-46D17 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-52E12 | ZFIN Curated Data | |
| Contains | SNP | rs3728105 | ZFIN Curated Data | |
| Contains | SNP | rs3728106 | ZFIN Curated Data | |
| Contains | SNP | rs3728107 | ZFIN Curated Data | |
| Contains | SNP | rs3728108 | ZFIN Curated Data | |
| Contains | SNP | rs3728109 | ZFIN Curated Data | |
| Contains | SNP | rs3728110 | ZFIN Curated Data | |
| Contains | SNP | rs3728111 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131550 (1) | 5619 nt | ||
| Genomic | GenBank:AL772193 | 192531 nt | ||
| Polypeptide | UniProtKB:F1QYZ6 (1) | 1181 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Lang, I., Virk, G., Zheng, D.C., Young, J., Nguyen, M.J., Amiri, R., Fong, M., Arata, A., Chadaideh, K.S., Walsh, S., Weiser, D.C. (2020) The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. International Journal of Molecular Sciences. 21(16):
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Delgadillo-Silva, L.F., Tsakmaki, A., Akhtar, N., Franklin, Z.J., Konantz, J., Bewick, G.A., Ninov, N. (2019) Modelling pancreatic β-cell inflammation in zebrafish identifies the natural product wedelolactone for human islet protection. Disease models & mechanisms. 12(1):
- Liu, H., Wang, X., Wu, Y., Hou, J., Zhang, S., Zhou, N., Wang, X. (2018) Toxicity responses of different organs of zebrafish (Danio rerio) to silver nanoparticles with different particle sizes and surface coatings. Environmental pollution (Barking, Essex : 1987). 246:414-422
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
- Sandoval, I.T., Delacruz, R.G., Miller, B.N., Hill, S., Olson, K.A., Gabriel, A.E., Boyd, K., Satterfield, C., Remmen, H.V., Rutter, J., Jones, D.A. (2017) A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).. eLIFE. 6
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