Gene
hsf1
- ID
- ZDB-GENE-000616-16
- Name
- heat shock transcription factor 1
- Symbol
- hsf1 Nomenclature History
- Previous Names
-
- hsf1a
- hsf1b
- HSF1c (1)
- zHSF1a
- zHSF1b
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables sequence-specific DNA binding activity. Acts upstream of or within lens development in camera-type eye and response to heat. Predicted to be located in nucleus. Is expressed in brain; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb286 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb287 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb294 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| mb30 | Allele with one deletion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mb31 | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR | |
| mb32 | Allele with one insertion | Unknown | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hsf1 | (3) | |
| CRISPR2-hsf1 | (2) | |
| CRISPR3-hsf1 | (2) | |
| CRISPR4-hsf1 | (2) | |
| MO1-hsf1 | N/A | (7) |
| MO2-hsf1 | N/A | Sugitani et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000232 | Heat shock factor (HSF)-type, DNA-binding |
| Domain | IPR010542 | Vertebrate heat shock transcription factor, C-terminal domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Heat shock factor (HSF)-type, DNA-binding | Vertebrate heat shock transcription factor, C-terminal domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LXV0 | InterPro | 497 | ||||
| UniProtKB:F6P697 | InterPro | 523 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-hsf1 | monoclonal | IgG1 | Rat |
|
Thermo Fisher Scientific (Lab Vision)
|
2 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(2A-GAL4-VP64-hsf1-PA-5xUAS-miniE1b-EGFP) |
| 1 | Zebrafish Nomenclature Committee | ||
| Tg(2A-GAL4-VP64-hsf1-PA-5xUAS-miniE1b-mCherry) |
| 1 | Zebrafish Nomenclature Committee | ||
| Tg(GAL4-VP64-hsf1,UAS:mCherry) |
| 1 | Zebrafish Nomenclature Committee | ||
| Tg(hoxd11a-2A-GAL4-VP64-hsf1,UAS:mCherry-2A-nsfb) |
| 1 | Zebrafish Nomenclature Committee |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-80H18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-251G8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162121 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001313736 (1) | 5951 nt | ||
| Genomic | GenBank:BX255894 (2) | 180950 nt | ||
| Polypeptide | UniProtKB:F6P697 (1) | 523 aa |
- Xiao, H., Li, M., Zhong, Y., Patel, A., Xu, R., Zhang, C., Athey, T.W., Fang, S., Xu, T., Du, S. (2025) Hsf1 is essential for proteotoxic stress response in smyd1b-deficient embryos and fish survival under heat shock. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 39:e70283e70283
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Lim, M.Y., Bernier, N.J. (2023) Intergenerational plasticity to cycling high temperature and hypoxia affects offspring stress responsiveness and tolerance in zebrafish. The Journal of experimental biology. 226(16):
- Sugitani, K., Mokuya, T., Homma, S., Maeda, M., Konno, A., Ogai, K. (2023) Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration. International Journal of Molecular Sciences. 24(4):
- Hariom, S.K., Nelson, E.J.R. (2022) Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish. Life sciences in space research. 34:21-29
- Lim, M.Y., Bernier, N.J. (2022) Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol. The Journal of experimental biology. 225(21):
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Gong, L., Zhang, Q., Pan, X., Chen, S., Yang, L., Liu, B., Yang, W., Yu, L., Xiao, Z.X., Feng, X.H., Wang, H., Yuan, Z.M., Peng, J., Tan, W.Q., Chen, J. (2019) p53 Protects Cells from Death at the Heatstroke Threshold Temperature. Cell Reports. 29:3693-3707.e5
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