Gene
foxh1
- ID
- ZDB-GENE-000616-15
- Name
- forkhead box H1
- Symbol
- foxh1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Located in chromatin. Is expressed in several structures, including nervous system; oocyte; pericardial region; presumptive diencephalon; and ventral mesoderm. Orthologous to human FOXH1 (forkhead box H1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55221 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 13 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| foxh1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| la012112Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| m768 | Allele with one point mutation | Unknown | Missense | ENU | |
| pr1 | Allele with one insertion | Unknown | Frameshift | spontaneous | |
| sa6241 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ty68b | Allele with one point mutation | Unknown | Missense | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-foxh1 | N/A | (6) |
| MO2-foxh1 | N/A | Pei et al., 2007 |
| MO3-foxh1 | N/A | Pei et al., 2007 |
| MO4-foxh1 | N/A | Nelson et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047511 | Forkhead box protein H1, forkhead domain |
| Family | IPR052327 | Activin-responsive transcriptional regulator |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Activin-responsive transcriptional regulator | Forkhead box protein H1, forkhead domain | Fork head domain | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R6J3 | InterPro | 472 | ||||||
| UniProtKB:Q9I9E1 | InterPro PDB | 472 | ||||||
| UniProtKB:B2GP52 | InterPro | 472 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9L5 | ZFIN Curated Data | |
| Contains | SNP | rs3728465 | ZFIN Curated Data | |
| Encodes | EST | fe26b06 | ZFIN Curated Data | |
| Encodes | EST | fi30c08 | ZFIN Curated Data | |
| Encodes | EST | fi32b01 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55221 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191388 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131502 (1) | 3192 nt | ||
| Genomic | GenBank:BX640453 (1) | 223071 nt | ||
| Polypeptide | UniProtKB:B2GP52 (1) | 472 aa |
- Prummel, K.D., Crowell, H.L., Nieuwenhuize, S., Brombacher, E.C., Daetwyler, S., Soneson, C., Kresoja-Rakic, J., Kocere, A., Ronner, M., Ernst, A., Labbaf, Z., Clouthier, D.E., Firulli, A.B., Sánchez-Iranzo, H., Naganathan, S.R., O'Rourke, R., Raz, E., Mercader, N., Burger, A., Felley-Bosco, E., Huisken, J., Robinson, M.D., Mosimann, C. (2022) Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nature communications. 13:1677
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Heigwer, J., Kutzner, J., Haeussler, M., Burkhalter, M.D., Draebing, T., Juergensen, L., Katus, H.A., Philipp, M., Westhoff, J.H., Hassel, D. (2020) miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Biochemical and Biophysical Research Communications. 527(2):432-439
- Pálfy, M., Schulze, G., Valen, E., Vastenhouw, N.L. (2020) Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation. PLoS Genetics. 16:e1008546
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Fischer, P., Chen, H., Pacho, F., Rieder, D., Kimmel, R.A., Meyer, D. (2019) FoxH1 represses miR-430 during early embryonic development of zebrafish via non-canonical regulation. BMC Biology. 17:61
- Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
- Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14
- Huang, C.X., Chen, N., Wu, X.J., He, Y., Huang, C.H., Liu, H., Wang, W.M., Wang, H.L. (2017) Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Life sciences. 171:21-29
- Joseph, S.R., Pálfy, M., Hilbert, L., Kumar, M., Karschau, J., Zaburdaev, V., Shevchenko, A., Vastenhouw, N.L. (2017) Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. eLIFE. 6
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