Gene
tbx20
- ID
- ZDB-GENE-000427-7
- Name
- T-box transcription factor 20
- Symbol
- tbx20 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; cloaca development; and regulation of cardiac muscle cell proliferation. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including cardiovascular system; digestive system; integument; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in atrial heart septal defect; atrial heart septal defect 4; congenital heart disease; tetralogy of Fallot; and ventricular septal defect. Orthologous to human TBX20 (T-box transcription factor 20).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 72 figures from 58 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb826 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| atrial heart septal defect 4 | Alliance | Atrial septal defect 4 | 611363 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PJM0 | InterPro | 447 | |||||
| UniProtKB:Q9I9K7 | InterPro | 446 | |||||
| UniProtKB:B3DJG4 | InterPro | 446 |
Interactions and Pathways
No data available
Plasmids
No data available